脑胶质瘤的临床治疗前景展望

Prospect of Clinical Treatment for Brain Glioma

脑胶质瘤传统的治疗方法以手术治疗为主,术后辅以放化疗,但疗效及预后很不乐观。由于显微神经外科技术的应用,加上近年来神经导航、影像学特别是脑功能成像、神经电生理监测等技术的快速发展,最大范围切除肿瘤而又能最大程度的保护脑功能已成为现实。但由于大部分胶质瘤具有浸润生长及恶性变的特性,术后复发在所难免。目前多采用神经导航、荧光引导下手术技术,术中辅以基因治疗、光动力学治疗、间质內放、化疗以及术后放、化疗、基因治疗、免疫治疗等协同作用,以期达到最佳的治疗效果。

Surgery is the main method in the traditional treatment for brain glioma. Postoperative radio-chemotherapy is usually conducted, but the curative effects and prognosis are unsatisfactory. Due to the application of the mieroneurosurgery technology and rapid development in neural navigation, neuroimaging, eerehral function imaging, and neural electrophysiologic monitoring, we can remove tumors completely and protect brain function to the utmost. However, postoperative relapse is unavoidable. At present, neuronavigatnr or fluorescence-guided microsurgery is frequently used, accompanied with adjuvant intra-operative gene therapy, photodynamic therapy, interstitial radiotherapy and chemotherapy, postoperative ehemo-radiotherapy, gene therapy and immunotherapy to attain the optimal therapeutic effects.