摘要
目的研究七氟醚、丙泊酚对神经外科长时间麻醉维持后苏醒时间等的影响。方法将50例神经外科择期手术患者随机分为七氟醚组和丙泊酚组各25例，麻醉维持首先根据BIS监测来调节七氟醚的吸入浓度或丙泊酚的静脉靶控浓度，使BIS维持在45～55之间，然后根据平均动脉压调节瑞芬太尼的输注速率，手术结束后停止麻醉药。观察两组的拔管时间、苏醒时间、定向力恢复时间、简单神经病学评估恢复时间等。结果七氟醚麻醉后拔管时间、苏醒时间、简单神经病学评估恢复时间均明显小于丙泊酚组（均P〈0．05），而定向力恢复时间，术后呕吐、寒战发生率差异无显著性。结论七氟醚和丙泊酚都适合于需要快速苏醒的神经外科麻醉，其中七氟醚苏醒更迅速。
Objective To compare the effects of sevoflurane/remifentanil and propofol/remifentanil on neurosurgery ansthesia. Methods Fifty patients undergoing intracranial surgery were randomly divided into two groups, propofol （P group） or sevoflurane （S group ） for maintaining anaesthesia. The concentration of sevoflurane or propofol was adjusted to maintain BIS during 45 -55. Remifentanil infusion rate was adjusted to keep the mean arterial blood pressure within 15% of the baseline. Drugs were withdrawn in the end of operation. Extubation, analepsia, orientation recovery, and the simple neurologic assessment recovery time were recorded. Results S group showed significantly shorter time of extubation, analepsia, and, simple neurologic assessment than those in the P group （ P 〈 0. 05 ）. The recovery time of orientation, and incidenc of postoperation nausea and vomiting showed no significant different between two groups. Conclusion Two anesthetics are both fit for the fast recovery requirement during neurosurgery procedures, sevoflurane is better than propofol.
出处
《医药导报》
CAS
2008年第2期193-195,共3页
Herald of Medicine
基金
浙江省医药卫生优秀青年人才专项科研基金资助项目(基金编号:2006QN022)
关键词
七氟醚
丙泊酚
神经外科
麻醉
苏醒
Sevoflurane
Propofol
Neurosurgery
Anesthesia
Recovery
