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卢比替康研究进展 被引量:1

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摘要 卢比替康属半合成喜树碱衍生物,该药通过抑制拓扑异构酶Ⅰ干扰DNA复制和细胞分裂。目前对卢比替康的研究已进入Ⅲ期临床试验,其中对胰腺癌的研究可使患者得到迄今最佳生存率。卢比替康对实体瘤具有广泛的抑制活性,对血液肿瘤亦有显著疗效,且可口服,毒性较小,是极具潜力的抗肿瘤新药。该文对其药理作用、作用机制、检测方法、药动学、临床研究和耐药性研究等作一综述。
出处 《医药导报》 CAS 2008年第2期204-207,共4页 Herald of Medicine
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共引文献62

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