海洛因依赖者执行功能损害的对照研究

Control study of execution functional lesion on heroin dependence

目的研究海洛因依赖者的执行功能状况。方法对124例海洛因依赖者和124例年龄、性别、受教育程度相匹配的正常对照者进行事件相关电位检测,同时采用Stroop字色干扰测验(C,CW)、连线测验、词语流畅及视觉记忆测验对海洛因依赖组和对照组分别进行测试。结果与对照组比较,海洛因依赖组Stroop-C、Stroop-CW总反应时间延长(P<0.05),Stroop-CW2 min反应数降低(P<0.05),且错误应答数增多(P<0.01);连线测验的完成时间延长及犯规次数增多(P<0.01);语言流畅和视觉记忆测验的成绩下降(P<0.01);事件相关电位N1、P2、N2、P3潜伏期延长(P<0.01)。结论海洛因依赖者存在一定程度的执行功能损害。

Objective To research the execution functional condition of heroin dependence. Methods 124 examples heroin dependence and 124 examples ages ,the sex, thenormal comparison and the education level which were matched with the heroin dependence were the carried on theevent related electric potential examination. Simultaneously the Stroop Color-Word Test （C, CW） , trail making test, verbal fluency and the visual memory examination were carried on the Heroin dependence group and control group. Results Compared with the control group,in heroin dependence group,the total reaction time of Stroop-C,Stroop Color-Word was longer（ P 〈 0.05 ） , the 2 min response number of Stroop-CW reduced （ P 〈 0.05 ） , the wrong answering number increased（ P 〈 0.01 ）. Complete time of trail making test lengthened and the number of breaking the rules increased（ P 〈 0.01 ）. The result of verbal fluency and the visual memory examination reduced（ P 〈 0.01 ）. The delitescence of event related potential N1 ,P2 ,N2 ,P3 lengthened（ P 〈 0.01 ）. Conclusion Execution functional lesion exist in heroin dependence.