子痫前期患者血清及胎盘激活素A水平变化的研究

The changing concentration of serum and placenta activin A in preeclampsia

目的 研究子痫前期患者血清及胎盘激活素A水平的变化及其与病情的关系。方法 采用ELISA检测40例子痫前期患者（子痫前期组，包括20例轻度，20例重度）和40例健康晚孕期妇女（正常妊娠组）的血清激活素A的水平；采用免疫组化方法检测胎盘激活素A的水平。结果 子痫前期组血清、胎盘激活素A水平分别为（32．23±6．11）μg/L、（516．14±5．46）μg/L，明显高于正常妊娠组的（8．04±2．19）μg/L、（275．38±18．12）μg／L（P〈0．01）；其中重度子痫前期患者血清、胎盘激活素A水平较轻度子痫前期患者升高（P〈0．01）；子痫前期组血清、胎盘激活素A水平与24h尿蛋白含量之间呈显著正相关；重度子痫前期伴胎儿生长受限（FGR）者血清胎盘激活素A水平较不伴FCR者差异均无统计学意义（P〉0．05）。结论 子痫前期患者血清、胎盘激活素A水平较健康晚孕期妇女显著升高，且与子痫前期病情进展关系密切。

Objective To investigate the alteration of serum and placenta activin A in women with preeclampsia,and study the relationship of them and pathogenetic condition. Methods The serum level and the placenta expression of activin A were assayed in 40 women with preeclarnpsia （preeclampsia group, 20 patients with mild preeclampsia and another 20 with severe preeclampsia） and 40 normal pregnant women （normal pregnant group） by specific ELISA and histochemistry. Results The serum and placenta concentrations of activin A were significantly higher in the preeclampsia group （32.23 ± 6.11 ）μ g/L, （516.14 ± 5.46） μ g/L, than those in the normal pregnant group （8.04 ± 2.19）μ g/L, （275.38 ± 18.12）μ g/L （P 〈 0.01 ）. Compared with patients of the mild preeclampsia, the serum and placenta activin A of the severe preeclampsia were significantly higher （P 〈 0.01 ）, and activin A levels were significantly correlated with the 24-hour proteinuria levels in the preeclampsia group. The serum and placenta activin A in the severe preeclampsia with fetal growth retardation （FGR） had no significant difference compared with those without FGR （P 〉 0.05 ）. Conclusion Serum levels and the placenta expression of activin A are significantly increased in women with preeclampsia, and they are correlated with the degree of severity of the disease.