摘要
[目的]观察鼻咽癌患者回输自体CIK细胞后免疫功能变化,探讨CIK细胞对鼻咽癌的治疗作用。[方法]收集鼻咽癌患者84例,分别抽取放化疗前后、CIK治疗后外周血作免疫指标检测。[结果]放化疗后,CD3+、CD4+细胞百分率下降,CD8+细胞百分率上升;CD4+/CD8+比值下调,Th1/Th2倒置,与放化疗前比较差异有显著性(P<0.05)。CIK治疗后上述指标较治疗前有改善(P<0.05),但绝对值未恢复到健康者水平。与放化疗前相比,放化疗后及CIK治疗后B细胞值变化无显著性差异(P>0.05),NK细胞百分率变化有显著性差异(P<0.05)。[结论]放化疗对鼻咽癌患者免疫功能有抑制作用。CIK治疗安全可靠,可以改善患者近期免疫功能。
[Purposel To investigate the immunity changes in patients with nasopharyngeal cancer （NPC） after cytokine induced killer （CIK） ceils being transfused back, and to explore the therapeutic effect of CIK cells on NPC patients. [Method] Tile immunity indexes in the peripheral blood of patients were detected in 84 cases with NPC befure/after radiochemotherapy and after CIK cells therapy. [Results] After radioehemotherapy, the percent age of CD3^＋,CD4^＋ eells declined, the percent age of CD8^＋ eells rose; the ratio of CD4^＋/ CD8^＋ declined, Thl/Th2 reversed. As all the above indexs compared with those before radinchemotherapy, the difference was significant （P〈0.05）. After CIK cell therapy, the above indexes improved （P〈0.05）, but the values were not returned to normal level. Compared to pre-radioehemotherapy, the change of the value of B cell was not significantly different （P〉 0.05）, while the change of percent age of NK cells was significantly different（P〈0.05） atier radiochemotherapy and alter CIK therapy. [Conclusions] Radiochemotherapy can inhibit the immunity in patients with NPC. CIK cells therapy is sale and effective. It may improve the recent immunity of the patients.
出处
《肿瘤学杂志》
CAS
2008年第1期35-37,共3页
Journal of Chinese Oncology
关键词
鼻咽肿瘤
杀伤细胞
免疫疗法
nasopharyngeal neoplasms
killer cell
ilnmunotherapy
