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MGMT表达与恶性肿瘤化疗关系的研究现状 被引量：5

Research Status of Relationship Between O6 Methylguanine DNA Methyltransferose (MGMT) Expression and Chemotherapy in Malignancies
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摘要 O6甲基鸟嘌呤DNA甲基转移酶(O6 methylguanine DNA methyltransferase,MGMT)是一种非常重要的DNA修复酶。肿瘤细胞对烷化剂耐药常与MGMT高表达有关。抑制MGMT的表达和活性,可能提高烷化剂疗效。文章就此进行综述。
作者 康马飞 秦自科
机构地区 桂林医学院附属医院 中山大学肿瘤防治中心
出处 《肿瘤学杂志》 CAS 2008年第1期67-70,共4页 Journal of Chinese Oncology
关键词 O6甲基鸟嘌呤DNA甲基转移酶(MGMT) 肿瘤 药物疗法
分类号 R730.53 [医药卫生—肿瘤]
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参考文献28

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二级参考文献39

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  • 5Nutt CL, Loktionova NA, Pegg AE, et al. O(6) methylguanine DNA methyltransferase activity, p53 gene status and BCNU resistance in mouse astrocytes [J]. Carcinogenesis, 1999, 20(12): 2361- 2365.
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  • 10Tanaka S, Kobayashi I, Oka H, et al. Drug resistance gene expression and progression of astrocytic tumors [J]. Brain Tumor Pathol, 2001, 18(2):131- 137.

共引文献69

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引证文献5

二级引证文献8

肿瘤学杂志
2008年 第1期

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