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非小细胞肺癌“细胞边界”CT确认的准确性研究 被引量:6

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摘要 目的验证非小细胞肺癌(NSCLC)CT确认的计划靶区(PTV)与病理学的"细胞边界"的一致性,为精确放疗提供客观和个体化的依据。方法47例CT确认可手术的NSCLC患者,CT分期≤Ⅲa,术前CT增强扫描,使用特定的TPS定义原发肿瘤PTV-T和淋巴结PTV-N,术后根据病理确定的"细胞边界"在TPS上重建的相应的临床靶区(CTV)CTV-T和CTV-N,分别计算PTV和CTV体积做比较分析。结果PTV-T和CTV-T的平均体积分别为124.7ml和122.6ml,说明PTV-T和CTV-T基本一致(t=0.87,P>0.1),但有5例PTV-T<CTV-T,说明外放15mm的"细胞边界"是不够安全的;CT对PTV-N勾划的敏感性为42.3%(41/97)、特异性为95.1%(39/41)。结论非小细胞肺癌CT确认的"细胞边界"即外放15mm是相对边界,局部转移的淋巴结也不完全遵循CT对转移淋巴结的确认标准,精确放疗的靶区设计更应突出个体化原则。
出处 《四川医学》 CAS 2008年第1期70-71,共2页 Sichuan Medical Journal
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参考文献8

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