肺硬化性血管瘤临床病理分析

Clinicopathologic analysis on pulmonary sclerosing hemangioma

目的探讨肺硬化性血管瘤(SHL)的组织来源及临床病理形态特征。方法对20例SHL进行组织学观察,免疫组织化学检测。结果肿瘤主要由实性区、乳头状区、血管瘤样区、硬化区4种构型以不同比例混合而成,肿瘤细胞是立方细胞和多角形细胞。立方细胞表达低分子细胞角蛋白8(CK8)、甲状腺转录子1(TTF-1)、上皮膜抗原(EMA);多角形细胞表达TTF-1、波形蛋白(Vim),部分表达EMA、突触素(Syn)、神经元特异性烯醇化酶(NSE)。结论肺硬化性血管瘤是起源于原始的呼吸道上皮的良性肿瘤,免疫组化检测有助于诊断及鉴别诊断。

Objective To investigate the origination and clinicopathologic features of sclerosing hemangioma in the lungs（SHL）. Methods Twenty cases of SHL were observed by clinicopathological and immunohistiochemical analysis. Results The tumor showed four patterns of solid, papillary, hemangioma-like and sclerotic. The main cells were cuboidal and pale polygonal cells. The cuboidal cells were cytokeretin 8（CK8）,thyroid transcription factor（TTF-1） and epithelial membrant antigen（EMA） positive, meanwhile the pale polygonal cells were TTF-1, vim etin positive and few cells showed EMA, synaptophysin（Syn）, neuron specific enolase（NSE） positive. Colclusion SHL is a benign entity that originates from primitive undifferentiated respiratory epithelium. Immunohistiochemistry plays an important role in the differential diagnosis.