摘要
目的研究褪黑素(MLT)与血压昼夜节律的关系。方法选门诊、住院患者及健康查体者88例分为非杓型高血压组、杓型高血压组及对照组;行24小时动态血压监测;同期测定患者白昼和黑夜尿6羟基硫酸褪黑素(6-SMT)含量,并计算黑夜/白昼尿6-SMT比值。结果(1)非杓型高血压组的夜间收缩压、舒张压及平均动脉压下降率均低于杓型高血压组和对照组(P〈0.01);杓型高血压组和对照组间差异无统计学意义(P〉0.05)。(2)各组患者的黑夜尿6-SMT含量高于白昼(P〈0.01);非杓型高血压组的黑夜尿6-SMT含量和黑夜/白昼尿6-SMT比值低于杓型高血压组和对照组(P〈0.01)。(3)在各组内,各黑夜/白昼尿6-SMT比值与其组夜间血压下降率均存在正相关(P〈0.05)。结论血压节律呈现杓型分布的杓型高血压组和对照组,其MLT在黑夜分泌较多;非杓型高血压组MLT黑夜分泌明显减少,与血压昼夜节律异常存在密切关系。
Objective To observe the association between melatonin (MLT) secretion and blood pressure changes during 24 hours in hypertensive patients (HPT) with (dipping) or without (non-dipping) night time blood pressure reduction. Methods The 2A-hour blood pressure and urine 6-SMT (6-sulfatoxymelatonin, metabolism product of MLT in urine ) in the daytime and nighttime were measured in normal control subjects ( n = 20 ), non-clipping HPT group ( n = 32 ) and dipping HPT group ( n = 36 ). Results As expected, blood pressure reduction during the night was significantly lower in non-dipping HPT group compared to control and dipping HPT groups. Nighttime 6-SMT was significantly higher than daytime 6-SMT in all groups and nighttime urine 6-SMT levels and ratio of nighttime/daytime urine 6-SMT levels were significantly lower in non-clipping HPT group compared to control and dipping HPT groups (all P 〈 0. 01 ). Moreover, ratio of nighttime/daytime urine 6-SMT levels are positively correlated blood pressure reduction during nighttime ( P 〈 0.05 ) in all groups. Conclusions Circadian rhythm of MLT secretion is maintained but nighttime MLT secretion was significantly reduced and related to disorders of circadian rhythm of blood pressure in non-dipping HPT group.
出处
《中华心血管病杂志》
CAS
CSCD
北大核心
2008年第1期20-23,共4页
Chinese Journal of Cardiology
关键词
褪黑激素
血压
昼夜节律
Melatonin
Blood pressure
Circadian rhythm