垂体腺瘤海绵窦侵袭的MRI表现与EMMPRIN和Galectin-3表达的相关性研究

Correlative study between MRI features of cavernous sinus invasion and expression of extracellular matrix metalloproteinase inducer and Galectin-3 in pituitary adenomas

目的:探讨垂体腺瘤海绵窦侵袭的MRI表现与基质金属蛋白酶诱导因子(EMMPRIN)和Galectin-3表达的相关性。方法:对34例垂体腺瘤患者术前行MRI检查,术后收集标本应用免疫组化SP法检测垂体腺瘤标本中EMMPRIN和Galectin-3表达,分析MRI表现与EMMPRIN和Galectin-3之间的关系。结果:垂体腺瘤海绵窦侵袭的MRI表现中,Knosp评分、Cottier评分、肿瘤形态不规则及双侧海绵窦段颈内动脉不对称性与EMMPRIN和Galectin-3表达有关(P<0.05)。结论:垂体腺瘤海绵窦侵袭MRI特征与EMMPRIN和Galectin-3相关,MRI可对垂体腺瘤海绵窦侵袭程度作出明确诊断。

Objective： To investigate the correlation between MRI features of cavernous sinus invasion and expression of extracellular matrix metalloproteinase inducer （EMMPRIN） and Galectin-3 in pituitary adenomas. Methods： MRI was performed preoperatively in 34 patients with histologically verified pituitary adenomas, EMMPRIN and Galectin-3 expression were determined by immunohistochemical SP method in all patients. The correlation between expression of determined proteins and MRI features between invasive and non-invasive pituitary adenomas were studied. Results： Among MRI invasive features, Knosp score, Cottier score, irregular tumor shape and bilateral intracavernous carotid artery asymmetry correlated with increased expression of EMMPRIN and Galectin-3 （P〈0.05）. Conclusion： MRI features of cavernous sinus invasion may be related to the expression of EMMPRIN and Galectin-3, MRI is very useful in diagnosing invasive extent of cavernous sinus in pituitary adenomas.