N-苄氧羰基氨基酸的合成

Synthesis of N-carboxyaminophenol

以甘氨酸和氯甲酸苄酯为原料,合成N-苄氧羰基甘氨酸,通过正交实验考察工艺条件对反应的影响。结果表明,最佳工艺条件为:底物摩尔比n(甘氨酸)∶n(氯甲酸苄酯)=1∶1,反应时间2 h,反应温度20℃,反应液pH值为9,收率90.2%。此法反应条件温和,操作简单,收率良好。

N-Carboxy glycine can be synthesized from glycine and benzyl chloroformate. The effect of level of each factor on reaction were researched by orthogonal experiment, optimum condition for the reaction were as follows：mole ratio of benzyl chloroformate to glycine 1 ： 1 ,reaction time 2 h, temperature 20 ℃, pH = 9. Under these conditions, the product yield was 90.2%.