妊娠期高血压疾病患者血清尾加压素Ⅱ对心脏形态及功能影响的研究

Effects of UrotensinⅡon cardiac shape and function in patients with pregnancy induced hypertension

目的探讨妊娠期高血压疾病患者血清尾加压素Ⅱ(UrotensinⅡ,UⅡ)水平对心脏形态及功能变化的影响。方法采用美国HP-5500型彩色多普勒超声诊断仪测量96例妊娠期高血压疾病患者及20例正常妊娠者孕晚期心脏房室腔大小、左室壁厚度,记录左室射血分数(EF)、心输出量(CO)、心脏指数(C I)作为评价心功能的指标,同时采用放射免疫法检测外周血中血清UⅡ水平。结果(1)与正常妊娠组对比,妊娠期高血压疾病组左室舒张末期室间隔厚度(IVSTd)、左室后壁厚度(LVPWTd)、左房收缩末期内径(LAD)均增加(P<0.01或<0.05),血清UⅡ水平升高,且其水平与上述各项指标均呈显著正相关关系(P均<0.05)。(2)左室功能比较,妊娠期高血压疾病各组CO、C I、EF与正常妊娠组相比,差异无显著性意义(P均>0.05)。结论妊娠期高血压疾病患者妊娠晚期血清UⅡ水平与心脏形态及功能改变有关,UⅡ可能参与妊娠期高血压疾病的心脏变化过程。

Objective： To investigate the effect of Urotensin Ⅱon cardiac shape and function in patients with pregnancy induced hypertension （PIH）. Methods： 96 patients with PIH, 20 normal pregnant （NP） women were examined by echocardiography, the diameters of atria, ventricles, thickness of left ventricular posterior wall and ventricular septum were measured with the American HP5500 echocardiogram., ejection fraction of left ventricle （EF）, cardiac output （CO） and cardiac index （CI） were determined, as the marker of cardiac function, the levels of plasma U Ⅱof peripheral blood were detected by radioimmuaoassay. Results： （ 1 ） The thickness of interventricular septum （IVSTd） and left ventricular posterior wall （ LVPWTd）, left atrium end - systolic diameter （LAD） were significantly enlarged in PIH than those in NP （ P 〈0. 01 or 〈0. 05）, the levels of plasma U Ⅱin PIH groups are significantly higher than those in NP （ all P 〈 0. 05 ）, the levels of plasma U Ⅱ were significantly positive correlated with other indexes （all P 〈 0. 05）. （2） To compared left ventricular function, EF, CO, CI in PIH has no statistics meaning than those in PN. Conclusion ： The levels of plasma U Ⅱ is related to the change of cardiac shape and function in patients with PIH, U Ⅱ may be involved in the changes of cardiac shape and function.