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腹腔液及异位内膜组织MCP-1、IGF-Ⅰ水平变化与子宫内膜异位症发病及不孕的相关性分析 被引量：1

The correlation between the changes of levels of MCP-1and IGF-Ⅰin peritoneal fluid and pathogenesis of endometriosis and infertility
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摘要 目的探讨子宫内膜异位症(Endometriosis,EM)患者腹腔液、异位内膜组织中单核细胞趋化蛋白-1(mon-ocyte chemotactic protein-1,MCP-1)、胰岛素样生长因子-I(Insulin-like growth factors-I,IGF-I)的变化在子宫内膜异位症发病及不孕中的作用。方法EM患者30例作为观察组,其中早期病例(Ⅰ-Ⅱ期)10例,晚期病例(Ⅲ-Ⅳ)20例;合并不孕症患者12例,非不孕症者18例。10例无内膜异位症者作为对照组。用酶联免疫检测(ELISA)方法测定两组腹腔液、内膜组织中的MCP-1、IGF-Ⅰ含量的变化。结果(1)内膜异位症组腹腔液、异位内膜组织中MCP-1、IGF-Ⅰ水平与对照组相比较有显著差异(P<0.01),且早期病例腹腔液MCP-1、IGF-Ⅰ水平及内膜组织MCP-1水平均明显高于晚期病例,差异显著(P<0.05)。(2)内异症合并不孕症患者腹腔液IGF-Ⅰ水平与非不孕症比较有显著差异(P<0.05)。结论内膜异位症患者腹腔液中MCP-1、IGF-Ⅰ的变化在子宫内膜异位症发病机制中具有一定作用。 Objective： The aim of the study was to investigate the role of monocyte chemotactic protein -1 （ MCP - 1 ） and Insulin- like growth factors -Ⅰ （IGF-Ⅰ） in the endometriosis pathogenesis and infertile. Methods： Peritoneal fluid and ectopic endometrial tissues of 30 patients with endometriosis （10 early stage and 20 severe stage; 12 with infertility and 18 without infertility） and 10 no - endometriosis were obtained . The ELISA was employed to measured MCP - 1 and IGF -Ⅰ levels. Results： （ 1 ） The levels of MCP- 1and IGF -Ⅰ in the peritoneal fluid and ectopic endometrial tissues were significantly elevated in EM group as compared with those in control group （10cases） （ P 〈0.01） ; especially the levels of MCP-land IGF -Ⅰ of the peritoneal fluid and MCP - 1 level of ectopic endometrial tissues were significantly higher in early stages than those in severe stages （ P 〈0.05 ）. （2） The level of peritoneal fluid IGF -Ⅰ was found to be significantly higher in patients with infertility than those of without infertility （ P〈0.05 ）. Conclusion ： Our results indicated that the changes of MCP -1 and IGF-Ⅰ may play some roles in the pathogenesis of endometriotic lesions.
作者 卢丽萍 卢杰平 潘莉莉 李强
机构地区 中国医科大学附属盛京医院 沈阳市苏家屯区妇婴医院妇产科
出处 《中国优生与遗传杂志》 2008年第2期59-61,共3页 Chinese Journal of Birth Health & Heredity
关键词 子宫内膜异住症 胰岛素样生长因子 单核细胞趋化蛋白-1 腹腔液 异位内膜组织 EM MCP-1 IGF-Ⅰ PF Ectopic endometrial tissues
分类号 R711.71 [医药卫生—妇产科学] R711.6 [医药卫生—妇产科学]
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参考文献8

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共引文献2

同被引文献16

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中国优生与遗传杂志
2008年 第2期

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