润肺止咳汤治疗小儿咳嗽变异性哮喘124例临床观察

Clinical Observation on 124 Cases of Infantile Cough Variant Asthma Treated by Runfei Zhike Decoction

目的观察润肺止咳汤治疗小儿咳嗽变异性哮喘的临床疗效及其对体外过敏源的影响。方法将小儿咳嗽变异性哮喘184例分为两组,治疗组124例用自拟润肺止咳汤,对照组60例用青霉素及氨茶碱,常规剂量治疗,3天为1个疗程,治疗2或3个疗程。治疗前及疗程结束后6～8周用放射过敏吸附试验(RAST)检测血清总IgE、吸入性过敏源、食入性过敏源各1次。结果治疗组总有效率(94.35%)明显优于对照组(75.00%,P<0.01),临床症状改善亦明显优于对照组。血清总IgE及体外过敏源转阴率均优于对照组。结论润肺止咳汤治疗小儿咳嗽变异性哮喘疗效显著,对血清总IgE及体外过敏源转阴有明显作用。

Objective To observe the effect of Runfei Zhike Decoction （Decoction for moistening the lung to stop cough） on infantile cough variant asthma （CVA） and the influence on in vitro allergic agent. Methods The 184 cases of infantile CVA were randomized into two groups. The treatment group （124 cases） was given the self-made Runfei Zhike Decoction, and the control group （60 cases） was given penicillin and aminophylline, with routine dosage for treatment, 3 days as one course, totally 2 or 3 courses. Before treatment and 6- 8 weeks after treatment finished, the serum total IgE, aspiration and ingestion allergic agents were examined once respectively with radioallergosorbent test （RAST）. Results The effective rate of treatment group was 94.35%, significantly superior to that of the control group （75.00%, P〈0. 01 ）, and so was the improvement of clinical symptoms; the serum total IgE and to-negative rate of in vitro allergic agent were both better than those of the control group. Conclusion Runfei Zhike Decoction is effective for CVA and has an obvious promotion on serum total IgE and to-negative change of in vitro allergic agent.