醒脑静注射治疗鞍区肿瘤术后下丘脑功能紊乱的临床研究

Clinical Therapeutic Observation of Xingnaojing Injection in Sellar Region Tumor Postoperative Hypothalamic Function Disorder

目的 评价醒脑静注射液在鞍区肿瘤术后下丘脑功能紊乱治疗中的临床疗效。方法 112例累及丘脑下部的鞍区肿瘤患者术后治疗随机分成两组,对照组46例,常规进行术前准备及术后处理,出现并发症后积极常规治疗。研究组66例,在对照组常规治疗的基础上加用醒脑静注射液10～20ml,1～2次/d。比较分析两组病例术后生命体征、中枢性高热、癫痫发作、消化道应激性溃疡以及颅内压和脑水肿等并发症的差异。结果 研究组：中枢性高热、颅内压、脑水肿、尿崩症、癫痫、消化道出血、血电解质紊乱等的发生率均较对照组低（P〈0.05或P〈0.01）。结论 巨大鞍区肿瘤术后早期应用醒脑静可以有效地控制和降低中枢性高热,减轻脑水肿,降低颅内压升高幅度,阻止下丘脑功能继发性损害,减轻术后并发症的程度,是提高鞍区肿瘤临床治疗效果的重要措施。

Objective To evaluate the clinical curative effect of Xingnaojing Injection on sellar region tumour postoperaive hypothalamic function disorders. Methods ..All 112 patients with tumor at sellar region postoperative treatment were randomly divided into two groups：Control group 46 cases, preoperative preparation and postoperative treatment were done ordinarily, the postoperative Com- plications were treated actively. Studing group 66 cases, postoperative treatment of the hypothalamie function disorders was added Xingnaojing Injection on the basis of the control group treatment. Contrast observe the difference of complication between the two groups. Results Incidence of Centrum Hyperthermia, reeoving consciousness, diabetes insipidus, blood electrolyte disorder, alimentary hemorrhage, seizure in studing group were lower than that in control group（ P 〈0. 05,orP 〈0. 01 ）. Conclusion It is effective for the postoperaive hypothalamie function disorders of sellar region tumor to apply Xingnaojing Injection in the early time to control the incidence rate,it could reduce the incidence rate of the postoperative complications, it is the key point to improve the clinical effect.