音乐刺激对急性有氧运动性疲劳大鼠纹状体及下丘脑5-羟色胺及去甲肾上腺素的影响

Effects of Music on 5-Hydroxytryptamine, Dopamine and Noradrenaline in Corpus Striatum and Hypothalamus of Rats in Acute Aerobic Exercise-Induced Fatigue

目的:研究音乐刺激对急性有氧运动性疲劳大鼠纹状体及下丘脑中5-羟色胺(5-HT)、及去甲肾上腺素(NE)代谢及功能的影响。方法:将50只大鼠分为安静对照组、运动后即刻处死组、运动后自然恢复组及运动后音乐恢复组。测试并比较各组大鼠纹状体及下丘脑中5-HT及NE的含量。结果:与自然恢复的大鼠相比,音乐刺激下大鼠纹状体NE含量升高显著,纹状体5-HT及下丘脑5-HT、NE水平亦有升高趋势。结论:大鼠在音乐环境中休息30min后下丘脑及纹状体均处于应激性兴奋状态,中枢疲劳性抑制暂时缓解,但音乐刺激并没有促进两脑区5-HT代谢恢复的作用。关于音乐疗法中枢作用机制的动物实验研究还有待于进一步探索。

Object： The effects of music on 5-hydroxytryptamine （5-HT） and noradrenaline （NE） in corpus striatum and hypothalamus of rats in acute aerobic exercise-induced fatigue were studied. Methods： 50 rats were randomly divided into the sedentary group （S）, the death right after exercise group （D）, the no-music after exercise group （NM） and the music after exercise group （M）. For all groups, the fluorescent intensities of 5-HT and NE in corpus striatum and hypothalamus were obtained and compared. Results： Compared with those of rats without music, NE levels in rat corpus striatum increased significantly after the rest with music, and also 5-HT levels in rat corpus striatum and 5-HT levels and NE levels in rat hypothalamus showed an increasing trend as well. Conclusions： After a 30-minute rest with music, there is high stress-induced excitation in rat striatum and hypothalamus and exereise-indueed central inhibition is reduced momentarily. However, the metabolism of 5-HT in the two brain regions is not recovered. Researches on the mechanism of music therapy on animals need further development.