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草酸与草酸钙晶体损伤肾脏的机制研究进展 被引量：3

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摘要 尿石症以肾结石多见，是一种严重影响人类健康的常见病和多发病，其中，80％以上的结石成分是草酸钙（CaOx）晶体。近年发现，暴露于高浓度草酸（0x）或CaOx晶体的肾脏上皮细胞会产生活性氧簇（ROS），导致自身损伤，细胞损伤的程度与晶体的浓度和接触晶体的时间成正比，
作者 黎承杨 邓耀良
机构地区 广西医科大学第一附属医院泌尿外科
出处 《中华实验外科杂志》 CAS CSCD 北大核心 2007年第12期1616-1618,共3页 Chinese Journal of Experimental Surgery
关键词 晶体损伤 草酸钙 肾脏 人类健康 结石成分 活性氧簇 上皮细胞 细胞损伤
分类号 R692.4 [医药卫生—泌尿科学]
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参考文献25

  • 1Thamilselvan S, Byer K J, Hackett RL, et al. Free radical scavengers, catalase and superoxide dismutase provide protection from oxalate-associated injury to LLC-PK1 and MDCK cells. J Urol,2000,164:224-229.
  • 2Huang MY, Chaturvedi LS, Koul S, et al. Oxalate stimulates IL-6 production in HK- 2 cells, a line of human renal proximal tubular epithelial cells. Kidney Int, 2005, 68:497-503.
  • 3Umekawa T, Chegini N, Khan SR. Increased expression of monocyte chemoattractant protein-1 ( MCP-1 ) by renal epithelial cells in culture on exposure to calcium oxalate,phosphate and uric.acid crystals. Nephrol Dial Transplant, 2003,18:664-669.
  • 4Umekawa T,Byer K,Uemura H,et al. Diphenyleneiodium ( DPI ) reduces oxalate ion- and calcium oxalate monohydrate and brushinte crystal-induced upregulation of MCP-1 in NRK52E cells. Nephrol Dial Transplant, 2005,20 : 870-878.
  • 5Habibzadegah-Tari P, Byer K J, Khan SR. Reactive oxygen species mediated calcium oxalate crystal-induced expression of MCP-1 in HK-2 cells. Urol Res, 2006, 34:26-36.
  • 6Miller C, Kermington L, Cooney R, et al. Oxalate toxicity in renal epithelial cells: characteristics of apoptosis and necrosis. Toxicol Pharmacol,2000,162 : 132-138.
  • 7Umekawa T, Iguchi M, Uemura H, et al. Oxalate ions and calcium oxalate crystalinduced up-regulation of osteopontin and monocyte chemoattractant protein-1 in renal fibroblasts. BJU Int, 2006,98 : 656-660.
  • 8Lieske JC, Hammes MS, Hoyer JR, et al. Renal cell osteopontin production is stimulated by CaOx monohydrate crystals. Kidney Int, 1997,51:679-686.
  • 9Toblli JE, Ferder L, Stella I, et al. Protective role of enalapril for hyperoxaluric tubulointerstitial lesions of hyperoxaluria. J Urol,2002,166 :275-280.
  • 10Toblli JE, Ferder L, Stella I, et al. Effects of angiotensin Ⅱ subtype 1 receptor blockade by 1 osatan on tubulointerstitial lesions caused by heperoxaluria. J Urol, 2002, 168:1550-1555.

同被引文献25

  • 1陈英剑,涂晓文,尹秋霞,胡成进.牛磺酸对糖尿病大鼠肾脏氧化和抗氧化系统的影响[J].放射免疫学杂志,2004,17(4):245-247. 被引量：8
  • 2郭宏骞,孙则禹.尿石症诊疗决策系列讲座(二)——含钙结石[J].中华医学信息导报,2006,21(20):22-22. 被引量：3
  • 3Johri N, Cooper B, Robertson W, et al. An update and practical guide to renal stone management. Nephron Clin Pract, 2010, 116 (3) :c159- c171.
  • 4Lieske J C, Toback F G. Interaction of urinary crystals with renal epithelial cells in the pathogenesis of nephrolithiasis. Semin Neph- ro1,1996,16(5) :458 -473.
  • 5Schepera M S, van Ballegooijen E S, Banglna C H, et al. Crystals cause acute necrotic cell death in renal proximal tubule cells, but not in collecting tubule ceils. Kidney Int, 2005,68 ( 4 ) : 1543 -1553.
  • 6Meimaridou E, Lobos E, Hothersall J S. Renal oxidative vulnera- bility due to changes in mitochondrial - glutathione and energy ho- meostasis in a rat model of calcium oxalate urolithiasis. Am J Physi- ol Renal Physiol,2006,291 (4) :F731 - F740.
  • 7Park J, Lee J, Choi C. Mitochondrial network determines intracel- lular ROS dynamics and sensitivity to oxidative stress through switc- hing inter - mitochondrial messengers. PLoS One, 2011,6 ( 8 ) : e23211.
  • 8Zuo J, Khan A, Glenton P A, et al. Effect of NADPH oxidase in- hibition on the expression of kidney injury molecule and calcium oxalate crystal deposition in hydroxy- L- proline -induced hyper- oxaluria in the male Sprague - Dawley rats. Nephrol Dial Trans- plant,2011,26(6) :1785 - 1796.
  • 9Thamilselvan V, Menon M, Thamilselvan S. Oxalate - induced ac- tivation of PKC - alpha and - delta regulates NADPH oxidase - mediated oxidative injury in renal tubular epithelial cells. Am J Physiol Renal Physio1,2009,297 (5) : F1399 - F1410.
  • 10Hanna I R, Taniyama Y, Szocs K, et al. NAD(P)H oxidase - derived reactive oxygen species as mediators of angiotensin II sig- naling. Antioxid Redox Signal,2002,4 ( 6 ) : 899 - 914.

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中华实验外科杂志
2007年 第12期

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