消癥丸对激素负荷大鼠子宫肌瘤的影响

Effect of Xiaozhengwan (消癥丸) on hysteromyoma induced by estrin-progestin in rats

目的:观察消癥丸对雌激素、孕激素负荷大鼠子宫肌瘤的影响。方法:采用雌激素、孕激素肌注的方法制备大鼠子宫肌瘤模型。连续给药4个月,末次给药后2h取血,电化学免疫法测血清中雌激素和孕激素水平;取子宫、卵巢,计算脏器系数,进行病理组织学检查。结果:模型对照组大鼠血清雌激素水平升高,子宫重量增加,瘤样增生。与模型对照组比较,消癥丸(960mg/kg)能显著降低激素负荷大鼠的血清雌二醇水平;消癥丸(960mg/kg、1440mg/kg)能降低大鼠子宫重量及脏器系数、子宫壁厚度;改善子宫的病理组织形态学。结论:消癥丸具有抗激素负荷大鼠子宫肌瘤的作用。

Objective： To observe the effect of Xiaozhengwan （XZW） on hysteromyoma of rats induced by estrogen-and-progesterone-burden. Methods： Hysteromyoma rat model was made by intramuscular injection of estrogen and progesterone. Wistar rats, female, after being treated for 4 months, the blood of rats was collected to assay the concentration of estrogen and progesterone in serum with electrochemiluminescence immtmoassay method 2 hours after the last administration, the uterus and ovary were removed to calculate its organ coefficient, and the uterus pathohistology examination was further done. Results： Estrogen in serum and weight of uterus in model rats were increased. Compared with model group, XZW （960 mg/kg） can decrease the level of estrogen in serum （P 〈 0.05 ） ; XZW （960 mg/kg, 1440 mg/kg） can decrease organ weight, organ coefficient and MUWT of uterus （ P 〈 0.05 - 0.01 ） ; improved the pathohistology characteristics of uterus under light microscope. Conclusion： Xiaozhengwan had the effect on anti-hysteromyomain estrogen-and-progesterone-burden rats.