间变性少突-星形细胞瘤

Anaplastic Oligoastrocytoma

间变性少突-星形细胞瘤依据世界卫生组织(WHO)2007病理学分类标准,分级为胶质瘤Ⅲ级。美国NCCN2007指引(Guideline)中,间变性少突-星形细胞瘤的治疗策略是尽最大限度切除肿瘤病灶,术后需要给予放疗和化疗,对于脑室开放者需要全脑放疗。我们收治一例肿瘤位于侧脑室旁的间变性少突-星形细胞瘤患者,该患者系年轻患者,手术时打开了侧脑室,行肿瘤全切除后未予放疗,而是结合肿瘤耐药基因MGMT检测结果(±),给予了12疗程的替莫唑胺化疗,该患者随访至今,无瘤生存已超过2年。本文就此病例的治疗进行讨论。

Anaplastic oligoastrocytoma （AOA） has been classified as glioma WHO grade Ⅲ According to the American NCCN guideline, the patients with AOA should receive total resection followed by the subsequent radiotherapy and chemotherapy. However, the patients should receive the whole brain radiotherapy if tumor invades to the lateral ventricles. We have treated a young female AOA patient with the tumor invaded to right lateral ventricle. The patient whose MGMT expression in the tumor was negative received total resection followed by chemotherapy with temozolomide for 12 cycles, and she received no radiotherapy. The tumor free survival of the patient has amounted to 2 years up to now. This article discussed this special case.