摘要
IΚB激酶家族(IΚB kinases,IKKs)是NF-ΚB信号途径最为重要的成员之一,已发现其在先天性免疫以及炎症反应的调节中发挥关键作用.除IKKα/β/γ之外,作为IKKs的最新成员,IKKε不仅具有与IKKα/β/γ类似的作用,而且最近的研究数据证实IKKε还能通过凋亡蛋白抑制物(inhibitor of apoptosis proteins,IAPs)调节caspases的活性,参加caspases的凋亡和非凋亡依赖性信号途径.
IκB kinases (IKKε) are vital components of the nuclear factor-κB signaling pathway, which play an important role in innate immune and inflammation responses. The newest member of the IKKs is IKKε, which has similar functions to IKKα/β /γand can act as a regulator of caspases by interacting with IAPs. Therefore, IKKε are a determinant of IAP level, and establish the threshold of activity required for the execution of non-apoptotic caspase functions.
出处
《世界华人消化杂志》
CAS
北大核心
2007年第33期3524-3526,共3页
World Chinese Journal of Digestology
基金
国家自然科学基金
No.30660066~~