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IΚB激酶家族新成员：IKKε 被引量：2

New member of the IΚB kinases:IKKε
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摘要 IΚB激酶家族(IΚB kinases,IKKs)是NF-ΚB信号途径最为重要的成员之一,已发现其在先天性免疫以及炎症反应的调节中发挥关键作用.除IKKα/β/γ之外,作为IKKs的最新成员,IKKε不仅具有与IKKα/β/γ类似的作用,而且最近的研究数据证实IKKε还能通过凋亡蛋白抑制物(inhibitor of apoptosis proteins,IAPs)调节caspases的活性,参加caspases的凋亡和非凋亡依赖性信号途径. IκB kinases （IKKε） are vital components of the nuclear factor-κB signaling pathway, which play an important role in innate immune and inflammation responses. The newest member of the IKKs is IKKε, which has similar functions to IKKα/β /γand can act as a regulator of caspases by interacting with IAPs. Therefore, IKKε are a determinant of IAP level, and establish the threshold of activity required for the execution of non-apoptotic caspase functions.
作者 曾朋 邓欢 刘亮明
机构地区 武警江西省总队医院外一科 南昌大学第二附属医院消化内科
出处 《世界华人消化杂志》 CAS 北大核心 2007年第33期3524-3526,共3页 World Chinese Journal of Digestology
基金 国家自然科学基金 No.30660066~~
关键词 IKKε CASPASE 凋亡 IKKε caspase Apoptosis
分类号 R341 [医药卫生—基础医学]
  • 相关文献

参考文献13

  • 1Peters RT,Liao SM,Maniatis T.IKKepsilon is part of a novel PMA-inducible IkappaB kinase complex.Mol Cell 2000; 5:513-522
  • 2Fitzgerald KA,McWhirter SM,Faia KL,Rowe DC,Latz E,Golenbock DT,Coyle AJ,Liao SM,Maniatis T.IKKepsilon and TBK1 are essential components of the IRF3 signaling pathway.Nat.Immunol.2003; 4:491-496
  • 3Seth RB,Sun L,Ea CK,Chen ZJ.Identification and characterization of MAVS,a mitochondrial antiviral signaling protein that activates NF-kappaB and IRF 3.Cell 2005; 122:669-682
  • 4Lin R,Lacoste J,Nakhaei P,Sun Q,Yang L,Paz S,Wilkinson P,Julkunen I,Vitour D,Meurs E,Hiscott J.Dissociation of a MAVS/IPS-1/VISA/Cardif-IKKepsilon molecular complex from the mitochondrial outer membrane by hepatitis C virus NS3-4A proteolytic cleavage.J Virol 2006; 80:6072-6083
  • 5Li XD,Sun L,Seth RB,Pineda G,Chen ZJ.Hepatitis C virus protease NS3/4A cleaves mitochondrial antiviral signaling protein off the mitochondria to evade innate immunity.Proc Natl Acad Sci U S A 2005; 102:17717-17722
  • 6Kravchenko VV,Mathison JC,Schwamborn K,Mercurio F,Ulevitch RJ.IKKi/IKKepsilon plays a key role in integrating signals induced by proinflammatory stimuli.J Biol Chem 2003; 278:26612-26619
  • 7Vaux DL,Silke J.IAPs,RINGs and ubiquitylation.Nat Rev Mol Cell Biol 2005; 6:287-297
  • 8Kuranaga E,Kanuka H,Tonoki A,Takemoto K,Tomioka T,Kobayashi M,Hayashi S,Miura M.Drosophila IKK-related kinase regulates nonapoptotic function of caspases via degradation of IAPs.Cell 2006; 126:583-596
  • 9Fernando P,Brunette S,Megeney LA.Neural stem cell differentiation is dependent upon endogenous caspase 3 activity.FASEB J 2005; 19:1671-1673
  • 10Schwerk C,Schulze-Osthoff K.Non-apoptotic functions of caspases in cellular proliferation and differentiation.Biochem Pharmacol 2003; 66:1453-1458

二级参考文献15

  • 1刘亮明,邓欢,张吉翔,罗杰.内毒素性急性肝损伤实验动物模型的建立[J].世界华人消化杂志,2006,14(1):12-18. 被引量：23
  • 2Eichmann A,Yuan L,Breant C,Alitalo K,Koskinen PJ.Developmental expression of pim kinases suggests functions also outside of the hematopoietic system.Oncogene 2000; 19:1215-1224
  • 3Heinrich PC,Behrmann I,Haan S,Hermanns HM,Muller-Newen G,Schaper F.Principles of interleukin (IL)-6-type cytokine signalling and its regulation.Biochem J 2003; 374:1-20
  • 4Kim KT,Baird K,Ahn JY,Meltzer P,Lilly M,Levis M,Small D.Pim-1 is up-regulated by constitutively activated FLT3 and plays a role in FLT3-mediated cell survival.Blood 2005; 105:1759-1767
  • 5Peltola KJ,Paukku K,Aho TL,Ruuska M,Silvennoinen O,Koskinen PJ.Pim-1 kinase inhibits STAT5-dependent transcription via its interactions with SOCS1 and SOCS3.Blood 2004; 103:3744-3750
  • 6Bachmann M,Moroy T.The serine/threonine kinase Pim-1.Int J Biochem Cell Biol 2005; 37:726-730
  • 7Fujii C,Nakamoto Y,Lu P,Tsuneyama K,Popivanova BK,Kaneko S,Mukaida N.Aberrant expression of serine/threonine kinase Pim-3 in hepatocellular carcinoma development and its role in the proliferation of human hepatoma cell lines.Int J Cancer 2005; 114:209-218
  • 8Mochizuki T,Kitanaka C,Noguchi K,Sugiyama A,Kagaya S,Chi S,Asai A,Kuchino Y.Pim-1kinase stimulates c-Myc-mediated death signaling upstream of caspase-3 (CPP32)-like protease activation.Oncogene 1997; 15:1471-1480
  • 9Palaty CK,Clark-Lewis I,Leung D,Pelech SL.Phosphorylation site substrate specificity determinants for the Pim-1 protooncogene-encoded protein kinase.Biochem Cell Biol 1997; 75:153-162
  • 10Cory S,Adams JM.The Bcl2 family:regulators of the cellular life-or-death switch.Nat Rev Cancer 2002; 2:647-656

共引文献3

同被引文献21

  • 1徐康,林正.自由基对转录因子NF-κB活性的调节[J].医学研究生学报,2004,17(7):654-656. 被引量：13
  • 2王婷玉,李俊.凋亡抑制蛋白的研究进展[J].安徽医药,2005,9(6):402-406. 被引量：8
  • 3Xi WU,Xunhao XIONG,Liping XIE,Rongqing ZHANG.Pf-Rel, a Rel/Nuclear Factor-κB Homolog Identified from the Pearl Oyster, Pinctada fucata[J].Acta Biochimica et Biophysica Sinica,2007,39(7):533-539. 被引量：11
  • 4Chen F,Castranova,Demers.New insights into the role of nuclear factor-kappaB,a ubiquitous transcription factor in the initiation of diseases.Clin Chem.45:7-17.
  • 5Fracchiolla NS,Lombardi L,Salina M,et al.Structural alterations of the NFkappa B transcription factor in lymphoidmalignancies.Oncogene,1993,8(10):2839-2845.
  • 6Sen R,Baltimore,D.Multiple.nuclear factors interact with the immunoglobulin enhancer sequences.Cell,1986,46(5):705-716.
  • 7Kazunori Hata,Akira Andoh,Mitsue Shimada,et al.IL-17 stimulates inflammatory responses via NF-κB and MAP kinase pathways in human colonic myofibroblasts.The Journal of Immunology,2002,169:1683-1687.
  • 8Justin Hartupee,Caini Liu,Michael Novotny.IL-17 enhances chemokine gene expression through mRNA stabilization.The Journal of Immunology,2007,179:4135-4141.
  • 9Paul P,Tak1,Gary S,Firestein2.NF-κB:a key role in inflammatory diseases.The Journal of Clinical Investigation,2001,107(1):7-11.
  • 10Beg AA,Baltimore D.An essential role for NF-kappaB in preventing TNF-alpha-induced cell death.Science,1996,274(5288):782-784.

引证文献2

二级引证文献10

世界华人消化杂志
2007年 第33期

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