利胆化瘀片的利胆消炎作用

Cholagogic and anti-inflammatory effects of Lidan Huavu tablets

目的:通过动物实验观察利胆化瘀片的利胆消炎作用.方法:以熊去氧胆酸为对照药物,测定健康大鼠单位时间内胆汁流量,观察利胆化瘀片对胆汁分泌及胆汁总胆红素及胆汁酸含量的影响.以阿司匹林为对照药物,采用二甲苯及冰醋酸建立炎症模型,观察利胆化瘀片对小鼠耳廓肿胀及血管通透性的影响.结果:利胆化瘀片明显增加胆汁分泌量,且随剂量增加而利胆效应增强,可持续3h以上,提高泌出胆汁、胆汁酸及总胆红素含量.低、中和高剂量组抑制小鼠因二甲苯所致的耳廓肿胀和对抗小鼠因冰醋酸所致的腹腔毛细血管通透性增加,与模型组比较差异有显著性(34.9%,39.5%,52.3%vs 0;38.6%,52.6%,55.5% vs 0,P<0.01).高剂量利胆化瘀片组利胆,促总胆红素和胆汁酸排出作用,与熊去氧胆酸组比较差异有显著性,抗炎作用与ASP相似.中剂量利胆化瘀片组促总胆汁酸排出与熊去氧胆酸组比较差异有显著性,对抗小鼠因冰醋酸所致的腹腔毛细血管通透性增加的作用与ASP相似.结论:利胆化瘀片具有明显的利胆消炎及促总胆红素及胆汁酸排泄的作用.

AIM： To observe the cholagogic and antiinflammatory effects of Lidan Huayu tablets in experimental animals.METHODS： Murine bile output was measured to observe the effects of Lidan Huayu tablets on bile secretion and the composition or ratio of bilirubin and bile acids. Ursodeoxycholic acid was used as a positive control. The antiinflammatory action of Lidan Huayu tablets was observed in a model of xylene-induced auricular swelling and acetic-acid-induced celiac microcapillary permeability in mice. Aspirin was used as a positive control. RESULTS： Compared with the normal saline group, the bile secretory volume in the Lidan Huayu tablet treatment group increased signifi-cantly in healthy rats in a dose-dependent manner, and this facilitating effect on bile excretion remained for 〉 3 h. The output of total bilirubin and bile acids was elevated. Xylene-induced auricular swelling and body twisting response to acetic acid were significantly reduced in mice treated with Lidan Huayu tablets. CONCLUSION： Lidan Huayu tablets possess strong cholagogic and anti-inflammatory effects and may promote the excretion of bilirubin and bile acids.