早期肠内营养联合肠屏障保护剂治疗急性重症胰腺炎64例

Treatment of 64 cases severe acute pancreatitis with early enteral nutrition and intestinal barrier protective agents

目的:探讨早期肠内营养联合肠屏障保护剂在急性重症胰腺炎治疗中的应用价值.方法:将64例SAP患者随机分三组,A组予常规治疗,B组在常规治疗基础上通过鼻空肠管给予早期肠内营养,C组通过鼻空肠管给予早期肠内营养并加用肠屏障保护剂.观察患者症状、体征、WBC、CRP、血淀粉酶恢复正常时间,其体质量及血清白蛋白变化情况以及对比其总住院费用、平均每天的住院费用及住院时间.结果:B组在症状、体症、WBC、CRP、血淀粉酶恢复时间以及住院时间、住院费用均明显优于A组(P<0.05).C组在CRP及白细胞数恢复时间上更是优于B组,但平均每天住院费用三组没有明显差异性(P>0.05).结论:在SAP治疗中应用鼻空肠管进行早期肠内营养联合肠屏障保护剂,可以改善SAP患者的营养状况,加快症状恢复,缩短病程,减少医疗费用.

AIM： To evaluate the efficacy of early enteral nutrition and intestinal barrier protective agents on severe acute pancreatitis （SAP）. METHODS： Sixty-four patients with SAP were randomly divided into groups A, B and C. Group A was given conventional therapy, group B enteral nutrition by nasogastric feeding, and group C enteral nutrition and intestinal barrier protective agents by nasogastric feeding. We measured the recovery time from symptoms, physical signs and laboratory parameters [white blood cell count 0NBC）, C-reactive protein （CRP） and serum amylase], changes in body weight and serum albumin, cost of hospitalization and length of stay. RESULTS： Recovery time from symptoms, physical signs and laboratory parameters in group B was significantly shorter than that in group A （P 〈 0.05）. Cost of hospitalization and length of stay in group B were better than those in group A （P 〈 0.05）. Recovery time of CRP and WBC in group C was significantly shorter than that in group B （P 〈 0.05）. Average daily hospitalization cost was comparable in the three groups. CONCLUSION： Treatment of SAP with early enteral nutrition and intestinal barrier protective agents can improve nutrition, speed up symptom recovery, shorten length of stay and reduce medical costs.