生长抑素垂体后叶素治疗食管静脉曲张破裂出血的疗效观察

Octreotide Posterior Pituitary for the treatment of acute bleeding from escphageal varices

目的比较生长抑素和垂体后叶素治疗肝硬化患者急性食管静脉曲张破裂出血的疗效和安全性。方法生长抑素8肽(奥曲肽Octreotide成都天台山制药有限公司)组30例,静推0.1mg后,然后以每小时25ug静脉滴注,维持48小时。垂体后叶素组28例,垂体后叶素30u最初10分钟之内,每分钟1u,其后每分钟0.1u维持静滴3～4天。观察两种药物的止血率,再出血率和副作用。结果生长抑素8肽组治疗有效率(90.00%),垂体后叶素组有效率(64.30%);两组再出血率分别为13.30%和39.30%。垂体后叶素组副作用发生率为46.40%,生长抑素8肽无明显副作用。结论生长抑素8肽是治疗急性食管静脉曲张破裂出血的一线有效药物。

Objective To compare the efficacy and safety of octreotide and pituitary for the treatment of acute variceal bleeding in cirrhotic patients. Methods of Patiens with acute variceal bleeding, were choose randomly to be given Octreotide（0.1mg and then 15ug/mint by intravenous injection）. The remaining were given pituitary （30u/10mint intravenous injection and then continuous infusion of 0.1u/3-4day）. Results success of therapy in Octreotide group （90.00%）and in pituitary group （64.30%）. The rates of repeated bleeding of the two group were 13.30% and 39.30%, side effects occurred in 46.40% of the patients treated with pituitary. There were no obvious side effects in the Octrectide group. Conclusions Octreotide is effective as first-line for the treatment of acute varieeal bleed in cirrhotic patients.