1An Gao Xu Shao Guang Li Ji Hong Liu Ai Hua Gan Research Laboratory of Digestive Disease,Huizhou Central People’s Hospital,Huizhou 516001,Guangdong Province,ChinaDr.An Gao Xu graduated from Guangdong Medical College in 1984.He is an associate physician-in-chief,specializing in the research and treatment of gastrointestinal and liver tumors.He has published 24 papers and 1 book..Function of apoptosis and expression of the proteins Bcl-2,p53 and C-myc in the development of gastric cancer[J].World Journal of Gastroenterology,2001,7(3):403-406. 被引量：91
3Kent S, Sabine H, Frank G. Human topoisomerase I forms double cleavage complexes on natural DNA [J]. Biochemical and Biophysical Research Communications, 2006, 349: 178- 185.
4James W. Molecular biology of the gene [M]. San Francisco, America : 13enjamin Cummings, 2004 : 121-125.
5Stewart Shuman. Vaccinia virus DNA topoisomerase: a model eukaryotic type IB enzyme [J]. Biochemica et Biophysica Acta, 1998,1400:321-337.
6Stewart Shuman. Characterization of vaccinia virus DNA topoi someraseI expressed in Escherichia coli [J]. The Journal of Biological Chemistry, 1988,263(31 ) : 16401-16407.
7Takeshi O, Eriko T, Osamu M, et al. NK314, a novel topoi- somerase 1I inhibitor, induces rapid DNA double strand breaks and exhibits superior antitumor effects against tumors resistant to other topoisomerase U inhihitors [J]. Cancer Let ters, 2008(259) : 99-110.
8Beverly Teicher. Next generation topoisomerase I inhibltors:Rationale and biomarker strategies [J]. Biochemical Pharma cology, 2008(75) ,1262-1271.
