2005～2006年北京地区肠道致病菌的分布及耐药状况

Distribution and resistance of enteric pathogenic bacteria in Beijing area from 2005 to 2006

目的监测近两年北京地区肠道致病菌的组成、流行趋势及耐药状况，为本地区的流行病学研究及临床合理用药提供依据。方法通过常规大便培养，筛选出致病菌后经生化及血清学进一步鉴定到种、群或血清型。结果肠道致病菌感染以男性为主，成年人多发，7～10月为腹泻发病高峰。病原以志贺菌属居首位，其次是弧菌；在志贺菌属中，宋内菌构成有增加趋势。各菌属及志贺菌属内各种群对抗生素的敏感率有差异。结论北京地区感染性腹泻的病原种类繁多，有性别、年龄、季节的分布特点，耐药性不同，应重视监测。

Objective To monitor the distribution, epidemic and resistance of enteric pathogenic bacteria in Beijing area in the last two years and to offer the data for guiding epidemiologic study and clinical treatment. Methods Enteric pathogenic bacteria were cultured and identified to species, group and serotype with the biochemical and serological test. Then the susceptibility of bacterium to antimicrobial agents was tested. Results Enteric pathogenic bacteria infections mostly in occurred male, adult patients, and became epidemic in July, August, September and October. Shigella spp. and Vibrio spp. were the main pathogenic bacteria of intestinal tract while, the rates of Shigella sonnei rose in Shigellae spp. , and with different antibiotic susceptibilites among them. Conclusion There were many species of enteric pathogenic bacteria causing infective diarrhea in our hospital. Their distributions were different in sexes, ages and seasons. The resistance rate was different, and surveillance should be continually strengthened.