关键生物技术的研究发展趋势预见分析

Analysis and prospect of trends of key R&D of biotechnology

目的:结合我国在全球生物技术发展中所处的位置,对重组蛋白、单克隆抗体、疫苗、干细胞、基因治疗、组织工程、生物芯片、蛋白质组、基因组等技术领域的生物关键技术进行趋势预见分析。方法:对科学引文索引(SCI)数据库中收录的文献与专利进行年度发展演化趋势和文献集中度研究,与生物技术产业发展现状进行对比,分析生物技术从基础研究到产品上市的技术演化路径,对未来技术发展领域进行预见。结果与结论:疫苗、干细胞、蛋白质组、基因治疗领域将是未来研究持续增长、资金投向较多的生物技术上游领域,而单克隆抗体、重组蛋白、疫苗是支撑市场发展的主要产品领域。

Objective：To study nine critical technologies,i.e.,recombinant protein,monoclonal antibody,vaccine,stem cells,gene therapy,tissue engineering,gene chips,proteomics,and genomics by literature and patent data mining,and to predict the future development of these technologies.Methods：From databases of Science Citation Index（SCI） and Biosis Previews nine critical technologies based on literature and patent data mining were studied.Annual literature distribution and aggregation trends,biotechnology product and industry status were discussed.By making comparisons with current technological development,the biotechnological development roadmap was analyzed and spheres technological development were forecasted.Results and Conclusion：Vaccines,stem cells,proteomics and gene therapy will enjoy sustained development with more funds in the upstream biotechnology.Monoclonal antibodies,recombinant protein and vaccine will remain the main product types in future biotechnology markets.