肾髓质间质细胞瘤临床病理观察

Renomedullary interstitial cell tumor:a clinicopathological study

目的探讨肾髓质间质细胞瘤的临床及病理组织学特征。方法通过光镜及免疫组化染色分析1例肾髓质间质细胞瘤,同时复习相关文献。结果肿瘤位于肾髓质锥体,肿瘤细胞呈小的星形或多边形,分布于疏松的间质中,伴胶原成分。肿瘤周边见正常的肾髓质小管陷入。免疫组化示瘤细胞vimentin（＋）,CD34小灶（＋）,desmin、S-100和CD117（-）。结论肾髓质间质细胞瘤临床检查不易被发现,常在成人尸体解剖时偶然发现。肿瘤位于肾髓质部位,直径大多在0.1～0.5 cm,确诊依赖于组织学检查。该肿瘤为良性,预后良好。

Objective To study the clinical and pathologic features of renomedullary interstitial cell tumor. Methods A case of renomedullary interstitial cell tumor was studied by using light microcopy and immunohistocbemical staining, with review of the relevant literature. Results The tumor was located in renal medalla pyramid, and small starry and polygonal tumor cells distributed in stroma containing collagen fibers. The entrapment of normal renal tubules was observed within periphery of the tumor, and calcium oxalate precipitated in normal renal medulla. Immunohistochemically, tumor cells showed positive reaction for vimentin,CD34 and negative for desmin, S-100 and CD117. Conclusion RICT is accidently found at autopsy, and usually locates in renal medulla. It is mostly 0.1 cm - 0.5 cm in diameter, and tends to escape clinical detection. RICT could be diagnosed with histopathologieal examination. RICT is a benign tumor and its prognosis is good.