醒脑静注射液对ICU重症肺炎患者血清细胞因子含量变化的影响

Effects of Xingnaojing injection on serum cytokines in patients with severe pneumonia in ICU

目的:探讨醒脑静注射液对重症肺炎患者血清细胞因子含量变化的影响。方法:按随机分组法将40例重症肺炎患者随机分为两组:治疗组20例在常规西药及人工机械通气治疗基础上加用醒脑静注射液;对照组20例仅用西药及人工机械通气等常规治疗;并将同期门诊健康体检者设为正常组进行比较。测定正常组及40例重症肺炎患者治疗前后血清TNF-α、IL-6及C反应蛋白(CRP)含量。结果:重症肺炎患者血清TNF-α、IL-6及CRP含量水平较正常组明显增高(P<0.05或P<0.01);治疗组治疗后d 5、7 TNF-α、IL-6水平下降幅度与本组治疗前及对照组治疗后比较有统计学差异(P<0.05);而治疗后治疗组与对照组CRP含量比较则无统计学差异。结论:TNF-α和IL-6是参与重症肺炎炎性反应的细胞因子,醒脑静可通过减轻细胞因子介导的炎性反应对重症肺炎的肺损伤起到保护作用。

AIM： To investigate the effects of Xingnaojing injection on sennn cytokines in patients with severe pneumonia in ICU. METHODS： 40 patients with severe pneumonia in ICU were randomly divided into two groups. 20 patients were infused Xingnaojing（XNJ group） and were treated with routine drugs and mechanical ventilation. Another in the control（C） group 20 patients were treated with drugs and mechanical ventilation. The normal （N） group was consisted of 20 health outpatients in the same period. Tumor necrosis factor-α （TNF-α）, interlukin-6（IL-6） and C-response protein（CRP） in plasma were measured before and after therapy in 40 patients with severe pneumonia and in the normal group. RESULTS： The levels of TNF-α, IL-6 and CRP of 40 patients were significantly higher than those in normal people （ P 〈 0.05, P 〈 0.01 ）. There was obviously lower level of TNF-α and IL-6 after therapy than before therapy in XNJ group and with C group at day 5 and（ P 〈 0.05）. But the level of CRP in all groups has no statistical significance. CONCLUSION： TNF-α and IL-6 are associated with inflammatory reaction of the severe pneumonia. Xingnaojing injection plays a lung injury protection role by reducing cytokine-mediated inflammatory response.