原发性肝癌术后早期复发的危险因素探讨

The investigation of the riskfactors of early recurrence after resection of HCC

目的:探讨原发性肝癌术后早期复发的临床相关因素。方法:回顾分析172例原发性肝癌行根治性切除术患者,从术前有无乙肝病毒感染、有无肝硬化、AFP及转氨酶(ALT)高低、肿瘤有无破裂出血、术中阻断肝门次数、肿瘤直径大小、有无包膜及术中术后有无输血等指标分析肝癌术后早期复发的相关因素。结果:原发性肝癌术后早期复发与术前ALT高低、有无肝硬化、肝癌有无破裂出血、术中肝门阻断次数及术中术后有无输血相关(P<0.05),而与术前AFP值、乙肝病毒感染状态、肿瘤大小、有无包膜无关(P>0.05)。结论:术前ALT升高、合并肝硬化、肝癌破裂出血、术中肝门阻断次数增多及术中或术后输血可能是原发性肝癌术后早期复发的危险因素。

Objective： To investigate the risk factors of early recurrence after resection of hepatocellular carcinoma（HCC）. Methods： 172 patients receiving radical resection of HCC were enrolled in this study ;some factors （disruption or bleeding,the envelope,the diameter of the tumor, the level of AFP and ALT preoperation, blockage of hepatic hilum, infection of HBV, hepatic cirrhosis, blood transfusion in or pestoperation） were reviewed. Results： the level of ALT preoperation, the blockage of hepatic hilum ,blood transfusion in or postoperation,hepatic cirrhosis and disruption or bleeding of tumor, were the risk factors for early recurrence after resection of HCC（ P 〈 0.05 ） ;however, the envelope and diameter of the tumor , infection of H BV , the level of AFP were nonsignificant （ P 〉 0. 05 ）. Conclusions ： the level of ALT preoperation, the blockage of hepatic hilum, blood transfusion in or postoperation, hepatic cirrhosis and disruption or bleeding of tumor are the risk factors for surgeon to estimate early recurrence after resection of HCC.