长期低剂量罗红霉素治疗慢性鼻窦炎

Longer course and lower dosage roxithromycin therapy for chronic sinusitis

目的:观察长期低剂量罗红霉素治疗慢性鼻窦炎的疗效。方法:对53例慢性鼻窦炎患者应用低剂量罗红霉素治疗,3、6个月后分别观察其症状,鼻内镜及鼻窦CT检查、鼻窦黏膜病理改善情况,同时检测治疗前后的糖精传输时间(ST)。结果:3、6个月后66.0%、71.7%鼻腔通气改善,64.1%、75.5%鼻涕量减少;75.0%、83.3%头痛减轻;31.6%、36.8%嗅觉改善;54.8%、69.0%鼻内镜检查好转;61.7%、68.1%CT扫描较用药前改善;41.7%、58.3%病理检查示鼻窦黏膜炎症减轻。平均ST治疗前为35.5±6.3min,用药3个月后为27.8±6.6min,6个月后为24.7±7.1min。结论:长期低剂量应用罗红霉素对治疗慢性鼻窦炎有较好的疗效。

Objective ：To investigate the therapeutic effect of longer course and lower dosage roxithromycin therapy on chronic sinusitis. Methods：Fifty three eases with chronic sinusitis were included in this study, treated in our hospital from Apr,2000 to Jan,2007. They were all treated with roxithromycin therapy in a way of longer course and lower dosage. Then, they were evaluated on the therapeutic effect of the therapy by symptoms inquring, nasal endoscopy, CT scanning on sinuses and saccharine transit time （STT） assay to detemine the improving status of lesion in sinuous mueosa, carried out by the end of third and sixth months respectively. Results：As determined at the two time points of the third and sixth months respectively, the improving rates of nasal respiratory function were 66.0% and 71.7% , the rates of nasal secretion reducing were 64.1% and 75.5% , the ones of headache relieving were 75.0% and 83.3%, the ones of olfactory, improving were 31.6% and 36.8% , the ones of mueosal improving as determined by endoscopy were 54.8% and 69.0% , the improving ones of CT images were 61.7% and 68. 1% , and the ones of pathohistological improving were 41.7% and 58.3% respectively. The averaged STT was 35.5 ±6.3 min. before the therapy. Following the therapy, it was 27.8 ± 6.6min. by the end of third month and it reached 24.7 ± 7.1 min. by the end of sixth month. Conclusion： The therapy with longer course and lower dosage roxithromycin is more effective for the treatment of chronic sinusitis.