谷胱甘肽治疗抗结核药所致肝损害的临床观察

The Clinical Observation of Curative Effect of Glutathione for Liver Function Injure Caused by Antituberculous Drugs

目的：探讨谷胱甘肽对抗结核药所致肝功能损害的临床疗效。方法：将抗结核药物引起肝损害病人221例分为治疗组（121例）和对照组（100例）。治疗组予基础治疗（肌苷、维生素C）加谷胱甘肽1.2～1.8g,静脉滴注,1次/d,对照组仅予基础治疗。结果：治疗组治疗后ALT、AST、TB较治疗前明显下降,经t检验,P〈0.05,有显著性差异。治疗组有效率92.6%,对照组有效率68.0%,经χ^2检验,P〈0.05,有显著性差异。结论：谷胱甘肽能有效治疗抗结核药所致肝功能损害。

Objective：To evaluate the clinical curative effect of glutathione used to liver function injure caused by antituberculous drugs.Methods： 221patients whose liver function injure caused by antituberculous drugs were divided into treatment group（121 cases） and control group（100 cases） randomly.The treatment group was given basic treatment（inosine,vitamin C） and glutathione（1.2～1.8g,iv infusion,once a day）.The control group was given basic treatment only.Results：The levels of AST,ALT,TB in the treatment group were obviously decreased after treatment,the diference was siginificant checked by t test（P〈0.05）.The effective rate was 92.6% in treatment group and 68.0% in control group,checked by χ^2,it also had siginificant diference.Conclusion：Glutathione can effectively cure liver function injure caused by antituberculous drugs.