超声辐射下合成1-[(未)取代苯酰基-3-[5-(1-苯基-3-甲基-5-氯吡唑-4-基)-1，3，4-噻二唑-2-基]-硫脲

Synthesis of 1-[(Un)substituted benzoyl]-3-[5-(1-phenyl-3-methyl-5-chloropyrazole-4-yl)-1,3,4-thiadiazol-2-yl]-thiourea under Ultrasonic Radiation

1-苯基-3-甲基-5-氯吡唑-4-甲酸与氨基硫脲在三氯氧磷中反应得到2-氨基-5-（1-苯基-3-甲基-5-氯吡唑-4-基）-1，3，4-噻二唑（1），然后分别采用超声辐射法和常规加热法与（未）取代苯甲酰基异硫氰酸酯（2）反应合成了一系列未见报到的1-[（未）取代苯酰基-3-[5-（1-苯基-3-甲基-5-氯吡唑-4-基）-1，3，4-噻二唑-2-基]-硫脲（3a～3j）．化合物的结构经元素分析，IR，^1HNMR确证．

2-Amino-5-（1-phenyl-3-methyl-5-chloropyrazol-4-yl）-1,3,4-thiodiazole （1） has been prepared by the reaction of 1-phenyl-3-methyl-5-chloropyrazol-4-carboxylic acid with aminothiourea in the presence of phosphorus oxychloride. Then a series of novel 1-[（un）substituted benzoyl]-3-[5-（1-phenyl-3-methyl-5- chloropyrazole-4-yl）-1,3,4-thiadiazol-2-yl]-thioureas （3a-3j） have been synthesized by the reaction of compound 1 with （un）substituted benzoyl isothiocyanates （2） by means of ultrasonic radiation heating method and ordinary method. The structures of these compounds were confirmed by elemental analysis, IR and ^1H NMR spectra.