^3H—二脱水伊地醇双甲磺酸酯在小鼠体内的吸收,分布和排泄

Absorption, Distribution and Excretion of 3 H 1,6 Dimesy1 2,3 4,5 Dianhydro L iditol ( 3 H DMDAI) in Mice

采用３Ｈ－标记药物的放射性测定法，测定了抗肿瘤药二脱水伊地醇双甲磺酸酯（ＤＭＤＡＩ）在小鼠体内的吸收、分布和排泄，并进行了药动学参数统计学处理。结果表明，ＤＭＤＡＩ静注时血药浓度分布快，但消除较慢。灌胃给药时吸收迅速。静注和灌胃时组织中分布均以胆汁及肝脏含量较高。静注７ｄ内药物在粪尿中排泄完全。

The absorption,distribution and excretion of antitumour drug 1,6 Dimesy1 2,3 4,5 Dianhydro L iditol(DMDAI) in mice were determined using tritium labeled compound and the two groups of pharmacokinetics parameters of iv and ig were computed and sorted by statistic method.The results showed that the drug concentration in plasma of 3 H DMDAI distributed faster,but eliminated slower after iv.The absorption of 3 H DMDAI was rapid when ig.administration.The drug distribution was found to be high in bile and liver when iv and ig. The total radioactivity was completely excreted in urine and feces within 7 days following iv injection, and it was not easily accumulated.