测定条件对旋光方向的影响

The Effect of Conditions Applied to Determine on the Rotatory Direction

有些光学活性分子因测定条件不同而改变旋光方向,因为不同条件下,分子构象发生了变化。构象改变后,分子结构内的螺旋方向改变,其旋光方向随之改变。测定条件变化,若不影响化合物构象,则其旋光方向不改变。

The rotatory direction determined under different conditions will be change for some optically active molecules. Because their conformations have been changed under different conditions. The change of the conformation will lead to the change of the helical direction in molecular structure. So that it results in change of the rotatory direction. This does not disagree with the rule of helix theory. When the changes of conditions applied to determine can not have influence on the conformation in molecular structure, the rotatory direction will not change.