2型糖尿病患者血清瘦素水平和胰岛素抵抗之间的关系

The relationship between the level of serum leptin and insulin resistance in type 2 diabetic patients

目的研究2型糖尿病患者与正常糖耐量人群之间瘦素水平的差异,探讨瘦素与肥胖和胰岛素抵抗之间的关系。方法收集30例2型糖尿病患者作为观察组,20例正常人群作为对照组,采用ELISA方法测量二组的瘦素浓度;用内环境稳定模型评估胰岛素抵抗程度。结果观察组瘦素浓度、空腹血糖、空腹胰岛素、胰岛素抵抗指数高于对照组(P<0.05);瘦素浓度与胰岛素抵抗指数呈正相关(P<0.05)。结论2型糖尿病患者血清瘦素水平显著升高,且与胰岛素抵抗有明显相关性。

Objective To investigate the relationship between the level of serum leptin and fat and insulin resistance through the difference of the leptin content in type 2 diabetic patients and the normal people. Methods The 30 type 2 diabetics and the 20 normal people were recruited, mesured the content of lepin by ELISA;assessed the degree of the insulin resistance by homeostasis model assessments. Results The contents of leptin, fasting serum glucose, insulin, insulin resistance index were higher in type 2 diabetics group than those of in the normal people group （P〈0.05）. The contents of leptin was positive correlation with the insulin resistance index（P〈0.05）. Conclusion The level of leptin is higher significantly in type 2 diabetics and the contents of leptin is positive correlation with the insulin resistance.