医务人员肺炎衣原体血清IgG抗体流行病学调查

Seroprevalence of Chlamydia pneumoniae specific IgG antibody in medical staffs

目的通过比较研究普通成年人和接诊呼吸道感染患者医务人员的血清肺炎衣原体(CP)抗体水平,探讨可能感染CP高危医务人群的CP血清流行病学状况。方法随机抽样湖北地区7所医院中经常接诊呼吸道感染患者自愿参加的健康医务人员,以问卷方式询问他们近2年发生呼吸道感染的机会;以ELISA法检测血清CP特异性免疫球蛋白G(SCPIgG)抗体,并与健康体检非医务成人SCPIgG抗体资料进行比较。结果102名健康医务人员[年龄(38±10)岁]SCPIgG抗体阳性率为14.7%,141名体检健康非医务人群[年龄(36±10)岁]SCPIgG抗体阳性率为16.3%,两组间率的差异无统计学意义,P=0.773。比较5所受调查人数较多的医院间SCPIgG抗体阳性率,差异无统计学意义,P=0.125。近2年有呼吸道感染较否认有相关感染的医务人员的SCPIgG抗体阳性率高(17.5%和12.9%),但差异无统计学意义,P>0.05。结论接诊呼吸道疾患的医务人员和医院,发生CP局部流行的机会可能不大。CP在成年人之间的传染性可能不强。

Objective To conduct a seroepidemiological survey of specific immunoglobulin G to Chlamydia pneumotdae （SCPIgG） in medical staffs who care for patients with respiratory illnesses. Methods Volunteers of medical staff responsible for respiratory infection from 7 hospitals in Hubei province were enrolled. A self-report standard questionnaire was used to assess the general state of well-being and the frequency of airway infection during recent two years. Sera from the medical staffs and from the age-matched healthy subjects of nonmedical occupation were tested by ELISA for SCPIgG. Results The seropositive rate of SCPIgG was 14.7% in 102 medical staffs, comparable to the 16.3% positive rate in 141 healthy subjects of nonmedical occupation （P = 0. 773）. The seropositive rate of SCPIgG in different hospitals enrolled in this survey was similar （P = 0. 125）. Those who had experienced airway infection in recent two years appeared to have higher seropositive rate of SCPIgG than those who denied of such infection （17.5% vs 12.9% ）, though there is no statistical significance （P〉0.05）. Conclusions The likelihood of C. pneumoniae endemic among medical staffs who care for respiratory illnesses is very low. Person to person spread of CP seems not to be efficient.