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甲基强的松龙对兔实验性脑血管痉挛的作用 被引量：2

Effect of methylprednisolone on cerebral vasospasm after subarachnoid hemorrhage
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摘要 目的探讨大剂量甲基强的松龙对蛛网膜下腔出血(SAH)后脑血管痉挛(CVS)的作用。方法将24只雄性新西兰白兔随机分成2组:SAH对照组和SAH+大剂量甲基强的松龙(MP,18mg/kg)治疗组。通过枕大池二次注血法构建SAH模型,观察MP对脑基底动脉的影响。应用酶联免疫生化技术检测各组兔基底动脉血管平滑肌细胞膜蛋白激酶C(PKC)活性。结果经脑血管造影证实该剂量甲基强的松龙明显减轻实验性脑血管痉挛的严重程度,与对照组相比,PKC活性在大剂量甲基强的松龙治疗组没有明显提高。结论大剂量甲基强的松龙能够明显减轻脑血管痉挛程度,通过抑制血管平滑肌细胞来防治脑血管痉挛的发生发展。 Objective To explore the effect of methylprednisolone（MP） on delayed cerebral vasospasm（CVS） after subarachnoid hemorrhage（SAH）. Methods Twenty-four male rabbits were randomly divided into two groups： non-treated group and high-dose MP treated group. We used methylprednisolone to treat the cerebral vasospasm after SAH, which was induced by single cistern injection of auto genous arterial blood in rabbits. Results The MP significantly reduced angiographic severity of vasospasm. In the treated group, PKC activity of the artery was not enhanced compared with non-treated group at any time. Conclusion The result suggests that MP could prevent vasospasm through inhibition of PKC activity.
作者 隋璐 沈薇 李玉芳 胡婕
机构地区 沈阳医学院基础部病理生理教研室 沈阳市第四人民医院内科
出处 《中国实用神经疾病杂志》 2008年第2期44-46,共3页 Chinese Journal of Practical Nervous Diseases
关键词 甲基强的松龙 脑血管痉挛 蛛网膜下腔出血 蛋白激酶C Methlprednisolone Cerebral vasospasm Subarachnoid hemorrhage Protein kinase C
分类号 R-332 [医药卫生]
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参考文献8

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二级参考文献52

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共引文献47

同被引文献22

  • 1王硕.脑血管痉挛防治神经外科专家共识[J].中国卒中杂志,2008,3(5):356-362. 被引量：79
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中国实用神经疾病杂志
2008年 第2期

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