喹硫平治疗儿童抽动障碍的对照研究

A comparative study of quetiapine in the treatment of tic disorder in children

目的探讨喹硫平对儿童抽动障碍的疗效和安全性。方法将81例抽动障碍患儿随机分为研究组和对照组,治疗前后应用耶鲁抽动症严重程度量表和副反应量表分别评定疗效及不良反应,共治疗8周。结果治疗第2周末、治疗第4周末及治疗第8周末,研究组和对照组的YGTSS总分较治疗前均有显著性降低(P<0.05),研究组各阶段的YGTSS总分均显著低于对照组(P<0.05)。在第4周末及第8周末,研究组和对照组的治疗有效率有显著性差异(P<0.05)。研究组的不良反应显著少于对照组(P<0.05)。结论喹硫平和氟哌啶醇对儿童抽动障碍均有较好疗效,但喹硫平的疗效和安全性更好。

Objective To explore the efficacy and safety of quetiapine in the treatment of tie disorder in children. Methods A total of 81 children with tic disorder were randomly divided into study group with quetiapine and control group with haloperidol for treatment of 8 weeks. They were assessed with Yale Global Tic Severity Scale （YGTSS） and Treatment Emergent Side Effect Scale （TESS） . Results In the 2nd, 4th and Child Tie disorder Quetiapine Haloperidol8th week- end,total scores of YGTSS both in study group and control group significantly decreased（P〈0.05）. But in every period, the total scores of YGTSS in study group were significantly lower than those in control group. The effective rates had significant differences between two groups in the 4th and 8th weekend（P〈0.05）. The side effects were significantly fewer in study group than those in control group. Conclusion Quetiaine and haloperidol both are effective to treat tic disorder, but quetiapine are more effective and safe.