冠心病患者血清DNA酶Ⅰ与超敏C反应蛋白检测的临床意义

Clinical significance of the determination of deoxyribonuclease Ⅰ and high sensitivity C-reactive protein in CHD patients

目的探讨血清DNA酶Ⅰ(DNaseⅠ)、超敏C反应蛋白(hs-CRP)质量浓度与冠状动脉病变范围、病变程度和临床风险的关系。方法选取2006年7月至12月华中科技大学同济医学院附属协和医院心内科住院患者,根据冠状动脉造影和临床表现,对112例冠心病(CHD)患者和57名正常人的血清DNaseⅠ与hs-CRP质量浓度进行比较。结果DNaseⅠ在稳定型心绞痛组[(152.63±24.16)μg/L]与对照组[(159.62±20.51)μg/L]差异无显著性意义(P>0.05),在不同冠状动脉病变范围组间、不同冠状动脉病变程度组间、急性冠脉综合征(ACS)与稳定型心绞痛组间的DNaseⅠ差异均有显著性意义(P<0.05);hs-CRP在单支病变组[(5.81±3.59)mg/L]和多支病变组[(6.62±5.18)mg/L]差异无显著性意义(P>0.05),在不同冠状动脉病变程度组间、不同临床分组间hs-CRP差异均有显著性意义(P<0.01)。冠心病患者血清DNaseⅠ和hs-CRP呈显著正相关(r=0.295,P<0.01)。结论联合检测DNaseⅠ与hs-CRP质量浓度有助于判断冠状动脉病变范围、病变程度和临床风险。

Objective To explore the relationship between the level of deoxyribonuclease Ⅰ （ DNase Ⅰ）, high sensitivity C-reactive protein（ hs-CRP） and extent, degree of pathology and clinical risk in coronary heart disease（CHD） patients. Methods A total of 112 patients and 57 normal objects having undergone coronary angiography were included in the study, hs-CRP and DNase Ⅰ of these samples were measured and compared according to the results of coronary angiography and clinical condition. Results There were no significant difference between normal[ （ 159. 62 ±20. 51 ） μg/L] and stable angina group[ （ 152. 63±24. 16 ） μg/L] in DNase Ⅰ level （ P 〉 0. 05 ） ; identical result presented in hs-CRP level between different degree of coronary artery pathology （P 〉 0. 05 ）. However, other groups based on different extent and degree of pathology ,clinical risk had significant difference in hs-CRP（ P 〈 0. 01 ） and DNase Ⅰ level（ P 〈 0. 05 ）. DNase Ⅰ level was positively correlated with hs-CRP level in CHD（ r =0. 295 ,P 〈 0. 01 ）. Conclusion The levels of hs-CRP and DNase Ⅰ help to evaluate the extent and degree of coronary artery pathology and clinical risk in CHD.