结直肠癌患者血清及粪便中热休克蛋白60检测的意义

Significance of feces and surem HSP60 in colorectal cancer patients

目的探讨粪便总热休克蛋白60检测的临床初筛诊断价值和意义。方法采用hHSP60蛋白ELISA试剂盒对40例结直肠癌患者、20例肠镜检查结果阴性健康人群的粪便和血清作人热休克蛋白(hHSP60)测定。所有患者术前未接受过任何放疗或化疗,术后均经常规组织病理证实。结果hHSP60浓度在结直肠癌患者血清中明显增高;hHSP60浓度在结直肠癌患者粪便中增高,并高于血清中人hHSP60浓度。结论检测粪便中hHSP60有望作为一种新的结直肠癌诊断或筛检方法。

Objective To demonstrate the detection of human HSP60（hHSP60）in feces could be a suitable marker in clinical diagnosis of colorectal cancer. Methods Choose the human total hHSP60 kit which were produced in R＆D system company to detect the contents of bliPS60 in 40 patients and 20 normal peoples＇ feces and serum. All patients did＇t accept radiotherapy and chemotherapy. They were all confirmed to be the patients of colorectal cancer. Results HSP60 content of cases with colorectal cancer was increased significantly in human serum. HSP60 content of cases with colorectal cancer was increased significantly in human feces, and higher than in human serum. Conclusion Detecting of HSP60 in feces would be a new method of screening colorectal cancer.