绝经后妇女认知功能障碍与ERα基因多态性关系

Study of relationship between ERα gene polymorphism and cognitive impairment in postmenopausal women

目的探讨绝经后妇女认知功能障碍与ERα基因多态性关系。方法60岁以上绝经妇女中随机抽取136例，简易智能量表（MMSE）检测的认知功能，放射免疫法测血浆雌二醇浓度，采用PCR扩增加限制性内切酶酶切的方法检测ERα基因多态性。结果认知功能障碍妇女血浆雌二醇水平低于对照组妇女，差异有统计学意义（P〈0．05）。ERαXx与认知功能障碍的相对危险度是ERαXX基因型的1．98倍（OR=1．98，95％CI：1．304～6．308，P=0．008），ERαXX与认知功能障碍的相对危险度是ERαXX基因型的1．56倍（OR=1．56，95％CI：0．681～4．515，P=0．242）。结论ERα基因多态性与绝经后妇女认知功能障碍有关。

Objective To explore the relationship between ERα gene polymorphism and the cognitive impairment in postmenopausal women. Methods One hundred and thirty six postmenopausal women aged 60 years old and over were randomly collected. Cognitive function was examined by MMSE. Density of estradiol was detected by radioimmunity and ERα gene polymorphism was measured by PCR. Results Compared with control group,women of cognitive impairment had an decreased level of estradiol（P〈 0.05）. Compared with ERαXX genetype,the relative risk of ERαXx with cognitive impairment was 1.98 times （OR=1.98,95 CI：1. 304-6. 308,P=0. 008）,the relative risk of ERαxx with cognitive impairment was 1.56 times（OR= 1.56,95%CI：0. 681-4. 515,P=0. 242）. Conclusion There is a relationship between ERα gene polymorphism and cognitive impairment in postmenopausal women.