摘要
目的研究丁苯酞等5个苯骈呋喃酮类化合物的质谱裂解特征。方法对于手性拆分的丁苯酞及丙苯酞采用质谱分析,丁烯苯酞的两个顺反异构体采用液相-质谱联用技术进行分离分析,并对5个苯骈呋喃酮类化合物的多级质谱裂解规律进行了详细解析。结果通过得到离子碎片的组成结构,可以进一步推断得出5个复杂的差向异构体或顺反异构体化合物形成碎片离子的裂解途径。结论该法简便、快速、准确,有助于对此类结构化合物更多的研究。
Objective To find a mass spectrum characterization of benzofuranone compounds. Methods 3-n-propylphthalide,two epimers,and two cis-trans-isomers were analyzed under electrospray ionization tandem mass spectrometry （ESI-MS^n） or HPLC/MS conditions, respectively. A detailed analysis of benzofuranone compounds was also reported. Results Molecular composition data of the fragment ions were obtained with the aid of comparison of the multiple tandem mass spectra of five compounds. Attempts have been made to provide rational pathways for the formation of the fragment ions from these protonated compounds. Conclusion The method is quick, precise and simple. The mass spectrum data will provide useful knowledge for the identification of unknown relative compounds for which no synthetic and isolated reference compounds are available.
出处
《河北医科大学学报》
CAS
2008年第1期66-70,共5页
Journal of Hebei Medical University
关键词
苯骈呋喃酮
光谱分析
质量
色谱法
高压液相
benzofuranones
spectrum analysis, mass
chromatography, high pressure liquid
