雷洛昔芬对去卵巢大鼠血脂的影响

The effect of raloxifene on blood lipid in ovariectomized rats

目的探讨选择性雌激素受体调节剂雷洛昔芬对去卵巢大鼠血脂的影响。方法将40只3月龄雌性SD大鼠随机分为5组,去卵巢组、假手术组、雌激素组、小剂量雷洛昔芬组(小剂量组)和大剂量雷洛昔芬组(大剂量组),每组8只。治疗3个月后,测量各组治疗前后体重、血压和血脂的变化。结果去卵巢组TC和LDL-C显著高于其他4组(P<0.01),雌激素组与假手术组比较无统计学差异(P>0.05),与小剂量组比较,大剂量组能更进一步降低TC和LDL-C(P<0.05)。去卵巢组TG与假手术组比较稍有升高,但无统计学差异,雌激素组TG高于假手术组和大、小剂量组(P<0.05)。去卵巢组HDL-C明显低于其他4组(P<0.01),雌激素组HDL-C与假手术组比较无统计学差异(P>0.05),与小剂量组比较,大剂量组能更进一步升高HDL-C(P<0.05)。结论雷洛昔芬可改善去卵巢大鼠的脂代谢状况,有助于降低绝经后的心血管危险。

Objective To investigate the effect of raloxifene,a selective estrogen receptor modulator, on blood lipid in ovariectomized rats. Methods Forty three-month-old female SD rats were randomly divided into five groups, ovarlectomy, sham operation, ovariectomy＋estrogen, ovariecto- my＋small dose raloxifene and ovariectomy＋large dose raloxifene. Body weight, blood pressure and serum lipid were measured after three months of treatment. Results Serum cholesterol（TC） and low-density lipoprotein（LDL-C） were significantly higher in ovariectomized rats than in other groups. Raloxifene could decrease TC and LDL-C （P〈0.05, P〈0.05）. Serum triglyceride（TG） was slightly increased after ovariectomy,and was higher in estrogen group than in sham operation group. Raloxifene could significantly decrease TG （P〈0.05）. Serum high-density lipoprotein （HDL-C） was significantly decreased after ovariectomy, and raloxifene could increase HDL-C （P〈0.05）. Conclusion Raloxifene could improve the lipid metabolism of ovariectomized rats, and benefit the prevention of cardiovascular disease.