番泻叶提取物的急性毒性实验研究

Empirical study of acute toxicity on Folium Sennae extractive

目的观察番泻叶提取物对小鼠的急性毒性反应。方法预实验初步确定用药剂量,正式实验取60只昆明种小鼠,用药剂量最低700倍,最高1 500倍,连续观察7 d,记录动物反应及死亡情况。结果各剂量组小鼠出现腹泻症状的程度与给药量呈正比,病理切片显示死亡小鼠符合低血容量性休克的病理改变。番泻叶提取物对小鼠急性毒性LD50=185.44 g/kg,相当于正常人用药量的1 112.6倍剂量。结论大量滥用番泻叶对肾、胃肠系统会造成较为严重的损害。

Objective It is to observe the rapid toxicity effect on Folium Sennae extractive. Methods After preliminary experiment to determine the dosage, 60 mice were selected and divided into 6 groups, the dosage were 700 multiple to 1 500 multiple. The reaction of mice was observed and recorded in the next 7 days. Results The degree of diarrhoea was different which depend on the dosage. The mouse pathological section showed： the deadly reason is hypovolemic shock. The acute toxicity of Folium Sennae extractive LD50 = 185.44 g/kg, the multiple was 1 112.6 times of normal. Conclusion Superfluous Folium Sennae can result in serious damage on kidney and digestive system.