摘要
目的观察番泻叶提取物对小鼠的急性毒性反应。方法预实验初步确定用药剂量,正式实验取60只昆明种小鼠,用药剂量最低700倍,最高1 500倍,连续观察7 d,记录动物反应及死亡情况。结果各剂量组小鼠出现腹泻症状的程度与给药量呈正比,病理切片显示死亡小鼠符合低血容量性休克的病理改变。番泻叶提取物对小鼠急性毒性LD50=185.44 g/kg,相当于正常人用药量的1 112.6倍剂量。结论大量滥用番泻叶对肾、胃肠系统会造成较为严重的损害。
Objective It is to observe the rapid toxicity effect on Folium Sennae extractive. Methods After preliminary experiment to determine the dosage, 60 mice were selected and divided into 6 groups, the dosage were 700 multiple to 1 500 multiple. The reaction of mice was observed and recorded in the next 7 days. Results The degree of diarrhoea was different which depend on the dosage. The mouse pathological section showed: the deadly reason is hypovolemic shock. The acute toxicity of Folium Sennae extractive LD50 = 185.44 g/kg, the multiple was 1 112.6 times of normal. Conclusion Superfluous Folium Sennae can result in serious damage on kidney and digestive system.
出处
《现代中西医结合杂志》
CAS
2008年第6期820-822,共3页
Modern Journal of Integrated Traditional Chinese and Western Medicine
基金
浙江省教育厅资助课题(06072)
关键词
番泻叶
急性毒性
提取物
Folium Sennae
acute toxicity
extractive