环氧化酶-2与胃癌
摘要
环氧化酶(COX)是花生四烯酸合成前列腺素(PGs)的限速酶,有两种亚型,即COX-1和COX-2,近来研究表明COX-2在消化系统肿瘤尤其是胃癌的发生发展、分化、转移等方面有重要作用。胃黏膜COX-2表达与幽门螺旋杆菌(Hp)感染有一定关系,COX-2特异性抑制剂有望成为肿瘤防治的一类新药。
出处
《现代医药卫生》
2008年第2期219-220,共2页
Journal of Modern Medicine & Health
参考文献13
-
1DANNHARDT G, KIEFER W.Cyclooxygenase inhibitors current stares and future prospects [J].Eur J Med Chem,2001,36(2):109.
-
2Zhang F, Warskwlat V, Wettstein M ,et al.Hyperosmolarity Stimulates prostaglandin synthesis and cyclooxygenase22 expression in activated rat liver macrophages[J].Biochem J, 1995,312(Pt 1): 135.
-
3Neil 1G P,Ford-Hutchinson A W.Expression of mRNA forcy-Clooxygenase--1 and cyclooxygenase-2 in human tissues[J].FEBS Lett, 1993, 330(2):156.
-
4Mclarthy CJ,Crofford LJ,Greensen J,et al.Cyclooxygenase-2 expression in gastricantral mucosa before and after eradication of Helicobacter pylori infection[J].Am J Gastroenterol, 1999,94:1218.
-
5陈永昌,张建中,李铁,盛涛,朱文玉.幽门螺杆菌诱导人胃上皮癌细胞株BGC-823环加氧酶-2的合成[J].北京大学学报(医学版),2001,33(2):144-146. 被引量:8
-
6KONTUKEK P C,HARTWICH A,ZUCHOWICZ M,et al.Helicobacter pylori,gastrin and cyclooxygenases in gastric cancer[J].J PhysiolPharmacol,2000,51(4):737.
-
7Moalic S,Liagre B,Le Ball JC.Dose dependent modulation of apoptosis and cyclooxygenase-2 expression in human I 547 osteosarcoma cells by NS-398 a selective cydooxygenase-2 inhibitor[J].Intemational journal of oncology ,2001,18(3):533.
-
8Jacoby RF, Cole CE,Tutsch K,et al.Chemopreventive efficacy of combiped piroxieam and flu orome thylomithine treatment of Ape mutant Min mouse adenomas and selective toxicity against Ape mutant embryos[J].Cancer Res,2000,60.
-
9CaoY ,Prescott ,S MM.anyactions of cyclooxygenase-2 in cellular dynamics and in can cer[J].JCell Physiol,2002, 190(3):279.
-
10MCLCMORE TL,HUBBARD W C,LITTERSTC L,et al. Profiles of prostaglandin biosynthesis in nomud lung and tumour tissue from lung eanee rpafient [J].CaneerRes,1988,48:3140.
二级参考文献8
-
1Sato N,Adv Exp Med Biol,1984年,180卷,763页
-
2Ohno R;YOSHINAGA K;FUJITA T.Depth of invasion parallels increased cyclooxygenase-2 levels in patients with gastric carcinoma[J],2001(10).
-
3Levy GN.Prostaglandin H synthases nonsteroidal anti-inflammatory drugs and colon cancer FASEB J,1997.
-
4Shiraishi N;Inomata M;Osawa N.Early and late recurrence after gastrectomy for gastric carcinoma[J],2000(02).
-
5Theuer CP;Kurosaki T;Ziogas A.Asian patients with gastric carcinoma in the United States exhibit unique clinical features and superior overall and cancer specific surival rates[J],2000(09).
-
6Murata H;Kawano S;Tsuji S.Cycooxygenase-2 overexpression enhances lymphatic invasion and metastasis in human gastric carinoma,1999(02).
-
7Chen CN;Sung CT;Lin MT.Clinicopathologic association of cyclooxygenase 1 and cyclooxygenase 2 expression in gastric adenocarcinoma[J],2001.
-
8陆红,戈之铮,刘文忠,陈晓宇,彭延申,萧树东.环氧合酶-2蛋白在结肠疾病中的表达[J].胃肠病学,2000,5(3):158-160. 被引量:38
共引文献12
-
1李莲,冯桂香,任永生,王伟,熊顺华.细菌脂多糖诱导人胃上皮癌细胞株BGC-823环氧化酶-2的合成[J].郧阳医学院学报,2004,23(2):85-87. 被引量:1
-
2刘改芳,姚希贤.幽门螺杆菌致癌机制中环氧合酶-2的作用[J].河北医科大学学报,2006,27(2):146-149. 被引量:9
-
3张彦普,刘改芳,徐华洲.幽门螺杆菌对不同分化程度胃癌细胞环氧合酶-2 mRNA及前列腺素E_2的影响[J].临床荟萃,2006,21(15):1098-1100. 被引量:2
-
4钱铖,孙为豪,刘顺英.环氧化酶与消化系统肿瘤[J].中国肿瘤,2001,10(11):667-670. 被引量:3
-
5赵凡,唐德才,张硕,郭秀霞,尹刚,戴建国.枳术颗粒对慢性萎缩性胃炎大鼠胃组织COX-2和VEGF表达的影响[J].中国实验方剂学杂志,2016,22(24):150-155. 被引量:11
-
6沈冰冰.环氧合酶-2与胃癌[J].临床消化病杂志,2003,15(1):40-42. 被引量:2
-
7孙晓岚,程红勤.非甾体抗炎药——环加氧酶与癌症治疗[J].牡丹江医学院学报,2003,24(6):42-44.
-
8王金华,岳黎敏,唐军民,孙大公,文宗曜.CFU-E和其分化细胞的生物物理特性[J].生物物理学报,2003,19(4):367-371. 被引量:1
-
9甘爱华,许岸高,刘集鸿,赵玉刚.胃癌前病变环氧合酶-2蛋白的表达及中医辨证[J].中国中西医结合急救杂志,2004,11(1):28-31. 被引量:16
-
10孙为豪,俞谦,曹大中,欧希龙,俞婷,钱铖,朱峰,孙运良.幽门螺杆菌感染和环氧合酶-2表达在胃癌发生中的作用[J].肿瘤,2004,24(1):38-41. 被引量:15
-
1黄晓舞.新型非甾体类抗炎药:西乐葆[J].中国药物应用与监测,2001(1).
-
2顾一珠,马平,王在震.塞来昔布衍生物SY3-1抗炎活性的初步研究[J].山东大学学报(医学版),2007,45(6):646-647.
-
3张伟,樊迎春,李瑛,喻志锋.COX-2特异性抑制剂的安全性与合理使用[J].中国药师,2007,10(10):1031-1033. 被引量:4
-
4肖汉龙,胡友红,罗建华.环氧化酶-2与皮肤肿瘤[J].中国麻风皮肤病杂志,2006,22(11):932-934.
-
5艾新波,潘文胜.COX-2及其选择性抑制剂在胃癌中的研究进展[J].国际消化病杂志,2008,28(3):199-200.
-
6曹国颖,胡欣,宋友华,傅得兴.环氧合酶特异性抑制剂——罗非昔布[J].中国医药导刊,2001,3(4):299-302.
-
7陈建达,徐辉.新一代COX-2特异性抑制剂——罗非昔布[J].海峡药学,2002,14(2):60-63. 被引量:1
-
8COX—2特异性抑制剂:骨关节炎、类风湿性关节炎治疗的一项突破[J].美国医学会杂志(中文版),2000,19(6).
-
9贺大银,熊利泽.非甾体抗炎药术后镇痛的临床应用进展[J].麻醉与监护论坛,2003,10(2):115-116.
-
10钱国栋,蒋维峥.胆石症伴消化系统恶性肿瘤15例分析[J].中国厂矿医学,1997,10(6):384-385.