摘要
报告1988和1989年期间进行的17例经培养的胎儿肾上腺髓质组织脑内尾状核头部移植治疗帕金森病(PD)的长期随访结果。17例患者术后6个月内临床效果较好日稳定;6个月至9个月间,5例症状复发;9至18个月间,2例症状复发;18个月至2年,2例患者症状复发;2年至3年间,2例患者症状复发;3年后,疗效消失。移植术提高了PD患者对抗PD药物的敏感性及药效。移植术后CT检查发现尾状核头部移植部位有空洞灶,提示移植组织死亡,或部分死亡,此时临床效果亦差。
Presented in this paper was the long term follow-up study on the transplantation of cultured embryonic adrenal medulla to the head of caudate in 17 patients with Parkinsonians from 1988 to 1989. The clinical response was good and stable 6 months after the operation in all patients; 5 patients had a relapse during 6 to 9 months; 2 during 9 to 18 months; 2 during 18 months to 2 years ; 2 during 2 to 3 years; one 3 years later. The patients showed a high sensitivity to antiparkinsonian drugs after the transplantation. In addition, if the cavity at the head of caudate was found after transplantation by CT, it was suggested that the graft tissue died, or partly died. At this time clinical response was not statisfactory.
出处
《中华器官移植杂志》
CAS
CSCD
1997年第3期140-141,共2页
Chinese Journal of Organ Transplantation