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DNA修复基因单核苷酸多态性在肿瘤化疗敏感性预测的应用进展 被引量：4

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作者 孙宁 陈宝安 孙新臣
机构地区 东南大学临床医学院 东南大学附属中大医院血液科
出处 《临床肿瘤学杂志》 CAS 2008年第1期88-92,共5页 Chinese Clinical Oncology
基金 全军医学科学技术研究“十一五”计划基金(06MA111) 江苏省自然科学基金前期预演项目(BK2005203) 南京市医学科技发展项目(ZKX0427)
关键词 单核苷酸多态性 DNA损伤修复 肿瘤 化疗敏感性
分类号 R730.45 [医药卫生—肿瘤]
  • 相关文献

参考文献35

  • 1Wood RD, Mitchell M, Sgouros J, et al. Human DNA repair genes [J]. Science, 2001,291(5507): 1284-1289.
  • 2Shi MM. Enabling large-scale pharmacogenetic studies by high throughput mutation detection and genotyping technologies [ J]. Clinical Chemistry, 2001,47(2) :164.
  • 3Savas S, Kim DY, Ahmad MF, et al. Identifying functional genetic variants in DNA repair pathway using protein conservation analysis [J]. Cancer Epidemiol Biomarkers Prey, 2004, 13(5) : 801 - 807.
  • 4Mollemann M, Wolter M, Felsberg J, et al. Frequent promoter hypermethylation and low expression of the MGMT gene in oligodendroglial tumors [J]. lnt J Cancer, 2005,20;113(3) : 379 - 385.
  • 5Rood BR, Zhang H, Cogen PH. Intercellular heterogeneity of expression of the MGMT DNA repair gene in pediatric medulloblastoma [J]. Neuro-oncol, 2004, 6(3) : 200 -207.
  • 6Okamoto R, Takano H, Okamura T, et al. O^6-methylguanineDNA methyhransferase (MGMT) as a determinant of resistance to camptothecin derivatives [ J]. Jpn J Cancer Res, 2002, 93 ( 1 ) : 93 - 102.
  • 7Hao B, Wang H, Zhou K, et al. Identification of genetic variants in base excision repair pathway and their associations with risk of esophageal squamous cell carcinoma [ J ]. Cancer Res, 2004, 64 (12) : 4378 -4384.
  • 8Stoehlmacher J, Ghaderi V, Iobal S, et al. A polymorphism of the XRCC1 gene predicts for response to platinum based treatment in advanced colorectal cancer [ J ]. Anticancer Res, 2001, 21 (4B) : 3075 -3079.
  • 9王中华,缪小平,谭文,张湘茹,徐兵河,林东昕.XRCC1单核苷酸多态与晚期非小细胞肺癌对铂类药物化疗敏感性的相关性[J].癌症,2004,23(8):865-868. 被引量：56
  • 10Gurubhagavatula S, Liu G, Park S, et al. XPD and XRCC1 genetic polymorphisms are prognostic factors in advanced non-smallcell lung cancer patients treated with platinum chemotherapy [J]. J Clin Oncol, 2004, 22(13): 2594-2601.

二级参考文献15

  • 1Risch NJ. Searching for genetic determinants in the new millennium [J]. Nature,2000,405:847- 856.
  • 2Weinshilboum R. Inheritance and drug response [J]. N Engl J Med,2003,348:529- 537.
  • 3Reed E. Platinum-DNA adduct, nucleotide excision repair and platinum based anti-cancer chemotherapy [J]. Cancer Treat Rev,1998,24:331- 344.
  • 4Rosell R,Lord RV,Taron M,et al. DNA repair and cisplatin resistance in non-small-cell lung cancer [J]. Lung Cancer,2002,38:217- 227.
  • 5Lunn RM,Langlois RG,Hsieh LL,et al. XRCC1 polymorphisms: effects on aflatoxin B1-DNA adducts and glycophorin A variant frequency [J]. Cancer Res,1999,59:2557- 2561.
  • 6Schiller JH,Harrington D,Belani CP,et al. Comparison of four chemotherapy regimens for advanced non-small-cell lung cancer [J]. N Engl J Med,2002,346:92- 98.
  • 7Zatloukal P,Petruzelka L,Zemanova M,et al. Gemcitabine plus cisplatin vs. gemcitabine plus carboplatin in stage Ⅲ b and Ⅳ non-small cell lung cancer: a phase Ⅲ randomized trial [J]. Lung Cancer,2003,41:321- 331.
  • 8Xing D,Qi J,Lin D,et al. Polymorphisms of DNA repair genes XRCC1 and XPD and their associations with risk of esophageal squamous cell carcinoma in a Chinese population [J]. Int J Cancer,2002,100:600- 605.
  • 9Xing D,Tan W,Lin D. Genetic polymorphisms and susceptibility to esophageal cancer among Chinese population(review)[J].Oncol Rep,2003,10:1615- 1623.
  • 10Duell EJ,Millikan RC,Pittman GS,et al. Polymorphisms in the DNA repair gene XRCC1 and breast cancer [J]. Cancer Epidemiol Biomarkers Prev,2001,10:217- 222.

共引文献62

同被引文献31

引证文献4

二级引证文献8

临床肿瘤学杂志
2008年 第1期

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