西酞普兰治疗脑卒中后抑郁对照研究的Meta分析

Meta-analyses of control studies on citalopram in the teatment of post-stroke depression

目的探讨西酞普兰治疗脑卒中后抑郁的临床疗效及安全性。方法应用Meta分析对6篇西酞普兰与其他抗抑郁剂治疗脑卒中后抑郁对照研究的文章进行再分析,评价其合并效应量大小。结果西酞普兰自身治疗前后的自身对照差异有极显著性(χ2=49.10,P<0.01),合并效应量d=-2.85,95%CI为(-5.42,-0.29)。西酞普兰与对照药物在第2w末和治疗后组间的比较,固定效应模型分析y合并=-0.22,95%CI(-0.42,-0.02),χ2=0.93,P>0.05;y合并=-0.10,96%CI(-0.29,0.10),χ2=1.00,P>0.05。提示两组疗效没有显著差异,但西酞普兰起效较快。结论西酞普兰与对照药物治疗脑卒中后抑郁的疗效相仿,但西酞普兰起效快。

Objective To explore the efficacy and safety of citalopram in the treatmrent of post-stroke depression. Methods Reanalyses were conducted with meta-analysis on the articles of 6 control studies of citalopram vs other antidepressants in the treatment of post-stroke depression and their merging effect quantity evaluated. Results There was very more significant difference in citalopram own-control between pre- and post-treatment（P〈0.01） and merging effect quantity d =-2.85,95%CI （-5.42,-0.29）; at the end of the 2nd week treatment and after teratment, intergroup comparisons of citalopram and control drugs supported fixed effect model analyses： Y emerging ：-0.22,95%CI （-0.42,-0.02）,χ2 =0. 93,P〉0.05;Yemerging =-0.10,96%CI （-0.29,0. 10）,χ2=1.00,P〉0.05, and which prompted that there was no significant difference in curative effect but citalopram took effects faster. Conclusion Citalopram has equivalent efficacy to the control drugs and takes effects faster in the treatment of post-stroke depression.