妊娠妇女补充核黄素、VA对缺铁性贫血影响

Impact of lactochrome and retinol supplementation on pregnant women with iron deficiency anemia

目的探讨补充核黄素、维生素A(VA)对妊娠妇女缺铁性贫血的影响。方法将贫血孕妇分为补铁组、补铁+核黄素组、补铁+VA组、补铁+核黄素+VA组。补充上述营养素60 d,观察补充前后血红蛋白、血清铁蛋白、血清转铁蛋白受体的变化情况。结果单独补铁、补铁+核黄素、补铁+VA、补铁+核黄素+VA均能显著提高妊娠妇女血红蛋白水平;补铁+VA组的血清铁蛋白明显高于补铁组(P<0.05);补铁+核黄素+VA组的血清铁蛋白明显高于补铁组、补铁+核黄素组、补铁+VA组(P<0.05),血清转铁蛋白受体显著低于补铁组、补铁+核黄素组、补铁+VA组(P<0.05)。结论单独补铁、补铁+核黄素、补铁+VA对改善缺铁性贫血均有明显效果,但铁、核黄素、VA等3种营养素同时补充,效果最好。

Objective To explore the effect of lactochrome and retinol supplementation on pregnant women with iron deficiency anemia. Methods Anemic pregnant women were divided into four groups and the levels of hemoglobin （Hb）, serum ferritin （SF） and serum transferrin receptor （STR） were determined before the trial. According to the doses of the trial, they were seperately supplemented with Fe, Fe ＋ VB2, Fe ＋ VA and Fe ＋ VB2 ＋ VA. The nutrients were supplemented for 60 days, the levels of hemoglobin, serum ferritin and serum transferrin receptor were determined again. Results The levels of Hb were significantly improved after supplementation with Fe, Fe ＋ VB2, Fe ＋ VA（P 〈 0.05） and Fe ＋ VB2 ＋ VA （ P 〈 0.01 ）. The levels of SF in Fe ＋ VB2 ＋ VA group were significantly higher than those in Fe, Fe ＋ VB2 and Fe ＋ VA groups（ P〈0.05）. The levels of STR in Fe ＋ VB2 ＋ VA group were the lowest of all groups（ P 〈 0.05）. Conclusion Supplementation with Fe, Fe ＋ VB2 or Fe ＋ VA respectively could improve the status of anemia, while the effect of improved status of anemia was the best if Fe ＋ VB2 ＋ VA were supplemented at the same time.